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@article{2405904,
author = {Rybnikář, Michal and Malaník, Milan and Šmejkal, Karel and Švajdlenka, Emil and Shpet, Polina and Babica, Pavel and Dall´Acqua, Stefano and Smištík, Ondřej and Jurček, Ondřej and Treml, Jakub},
article_location = {BASEL},
article_number = {6},
doi = {http://dx.doi.org/10.3390/ijms25063465},
keywords = {anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis},
language = {eng},
issn = {1661-6596},
journal = {International Journal of Molecular Sciences},
title = {Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects},
url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects},
volume = {25},
year = {2024}
}
TY - JOUR
ID - 2405904
AU - Rybnikář, Michal - Malaník, Milan - Šmejkal, Karel - Švajdlenka, Emil - Shpet, Polina - Babica, Pavel - Dall´Acqua, Stefano - Smištík, Ondřej - Jurček, Ondřej - Treml, Jakub
PY - 2024
TI - Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
JF - International Journal of Molecular Sciences
VL - 25
IS - 6
SP - 1-16
EP - 1-16
PB - MDPI
SN - 16616596
KW - anti-inflammatory
KW - antioxidant
KW - dibenzocyclooctadiene
KW - gap junction
KW - lignan
KW - Schisandra chinensis
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects
N2 - Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.
ER -
RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET, Pavel BABICA, Stefano DALL´ACQUA, Ondřej SMIŠTÍK, Ondřej JURČEK and Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. \textit{International Journal of Molecular Sciences}. BASEL: MDPI, 2024, vol.~25, No~6, p.~1-16. ISSN~1661-6596. Available from: https://dx.doi.org/10.3390/ijms25063465.
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