Dibenzocyclooctadiene Lignans from Schisandra chinensis with
Anti-Inflammatory Effects

J 2024

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET et. al.

Basic information

Original name

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

Authors

RYBNIKÁŘ, Michal (203 Czech Republic, belonging to the institution), Milan MALANÍK (203 Czech Republic, belonging to the institution), Karel ŠMEJKAL (203 Czech Republic, belonging to the institution), Emil ŠVAJDLENKA (203 Czech Republic, belonging to the institution), Polina SHPET (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic), Stefano DALL´ACQUA (380 Italy), Ondřej SMIŠTÍK (203 Czech Republic, belonging to the institution), Ondřej JURČEK (203 Czech Republic, belonging to the institution) and Jakub TREML (203 Czech Republic, belonging to the institution)

Edition

International Journal of Molecular Sciences, BASEL, MDPI, 2024, 1661-6596

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600 in 2022

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/ijms25063465

UT WoS

001193322800001

Keywords in English

anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis

Abstract

V originále

Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.

Links

GA23-04655S, research and development project

Name: Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Investor: Czech Science Foundation, Role of prenylation and glycosylation patterns in anti-inflammatory activity and metabolism of natural phenolic compounds

LM2023069, research and development project

Name: Výzkumná infrastruktura RECETOX

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX research infrastructure

Citovat

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET, Pavel BABICA, Stefano DALL´ACQUA, Ondřej SMIŠTÍK, Ondřej JURČEK and Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International Journal of Molecular Sciences. BASEL: MDPI, 2024, vol. 25, No 6, p. 1-16. ISSN 1661-6596. Available from: https://dx.doi.org/10.3390/ijms25063465.

@article{2405904,
   author = {Rybnikář, Michal and Malaník, Milan and Šmejkal, Karel and Švajdlenka, Emil and Shpet, Polina and Babica, Pavel and Dall´Acqua, Stefano and Smištík, Ondřej and Jurček, Ondřej and Treml, Jakub},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/ijms25063465},
   keywords = {anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis},
   language = {eng},
   issn = {1661-6596},
   journal = {International Journal of Molecular Sciences},
   title = {Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects},
   url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2405904
AU  - Rybnikář, Michal - Malaník, Milan - Šmejkal, Karel - Švajdlenka, Emil - Shpet, Polina - Babica, Pavel - Dall´Acqua, Stefano - Smištík, Ondřej - Jurček, Ondřej - Treml, Jakub
PY  - 2024
TI  - Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
JF  - International Journal of Molecular Sciences
VL  - 25
IS  - 6
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 16616596
KW  - anti-inflammatory
KW  - antioxidant
KW  - dibenzocyclooctadiene
KW  - gap junction
KW  - lignan
KW  - Schisandra chinensis
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects
N2  - Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.
ER  -

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET, Pavel BABICA, Stefano DALL´ACQUA, Ondřej SMIŠTÍK, Ondřej JURČEK and Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. \textit{International Journal of Molecular Sciences}. BASEL: MDPI, 2024, vol.~25, No~6, p.~1-16. ISSN~1661-6596. Available from: https://dx.doi.org/10.3390/ijms25063465.

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