| JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ and Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. PLANTS-BASEL. BASEL: MDPI, 2024, vol. 13, No 9, p. Neuvedeno, 10 pp. ISSN 2223-7747. Available from: https://dx.doi.org/10.3390/plants13091181. |
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@article{2405907,
author = {Jankovská, Dagmar and Jurčová, Nikol and Kubínová, Renata and Václavík, Jiří and Švajdlenka, Emil and Mascellani, Anna and Marsik, Petr and Bouzková, Kateřina and Malaník, Milan},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.3390/plants13091181},
keywords = {AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine},
language = {eng},
issn = {2223-7747},
journal = {PLANTS-BASEL},
title = {Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives},
url = {https://pubmed.ncbi.nlm.nih.gov/38732396/},
volume = {13},
year = {2024}
}
TY - JOUR
ID - 2405907
AU - Jankovská, Dagmar - Jurčová, Nikol - Kubínová, Renata - Václavík, Jiří - Švajdlenka, Emil - Mascellani, Anna - Marsik, Petr - Bouzková, Kateřina - Malaník, Milan
PY - 2024
TI - Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
JF - PLANTS-BASEL
VL - 13
IS - 9
SP - Neuvedeno
EP - Neuvedeno
PB - MDPI
SN - 22237747
KW - AChE
KW - Amorpha fruticosa
KW - BuChE
KW - molecular docking
KW - putrescine
KW - spermidine
UR - https://pubmed.ncbi.nlm.nih.gov/38732396/
N2 - Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
ER -
JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ and Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. \textit{PLANTS-BASEL}. BASEL: MDPI, 2024, vol.~13, No~9, p.~Neuvedeno, 10 pp. ISSN~2223-7747. Available from: https://dx.doi.org/10.3390/plants13091181.
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