Anticholinesterase Activity of Methanolic Extract of Amorpha
fruticosa Flowers and Isolation of Rotenoids and Putrescine and
Spermidine Derivatives

J 2024

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA et. al.

Basic information

Original name

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

Authors

JANKOVSKÁ, Dagmar (203 Czech Republic, belonging to the institution), Nikol JURČOVÁ (203 Czech Republic, belonging to the institution), Renata KUBÍNOVÁ (203 Czech Republic, belonging to the institution), Jiří VÁCLAVÍK (203 Czech Republic, belonging to the institution), Emil ŠVAJDLENKA (203 Czech Republic, belonging to the institution), Anna MASCELLANI, Petr MARSIK (203 Czech Republic), Kateřina BOUZKOVÁ (203 Czech Republic) and Milan MALANÍK (203 Czech Republic, belonging to the institution)

Edition

PLANTS-BASEL, BASEL, MDPI, 2024, 2223-7747

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10611 Plant sciences, botany

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.500 in 2022

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/plants13091181

UT WoS

001220531500001

Keywords in English

AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine

Abstract

V originále

Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.

Links

EF18_046/0015974, research and development project

Name: Modernizace České infrastruktury pro integrativní strukturní biologii

LM2023042, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministry of Education, Youth and Sports of the CR, CIISB - Czech Infrastructure for Integrative Structural Biology

Citovat

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ and Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. PLANTS-BASEL. BASEL: MDPI, 2024, vol. 13, No 9, p. Neuvedeno, 10 pp. ISSN 2223-7747. Available from: https://dx.doi.org/10.3390/plants13091181.

@article{2405907,
   author = {Jankovská, Dagmar and Jurčová, Nikol and Kubínová, Renata and Václavík, Jiří and Švajdlenka, Emil and Mascellani, Anna and Marsik, Petr and Bouzková, Kateřina and Malaník, Milan},
   article_location = {BASEL},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/plants13091181},
   keywords = {AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine},
   language = {eng},
   issn = {2223-7747},
   journal = {PLANTS-BASEL},
   title = {Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives},
   url = {https://pubmed.ncbi.nlm.nih.gov/38732396/},
   volume = {13},
   year = {2024}
}

TY  - JOUR
ID  - 2405907
AU  - Jankovská, Dagmar - Jurčová, Nikol - Kubínová, Renata - Václavík, Jiří - Švajdlenka, Emil - Mascellani, Anna - Marsik, Petr - Bouzková, Kateřina - Malaník, Milan
PY  - 2024
TI  - Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
JF  - PLANTS-BASEL
VL  - 13
IS  - 9
SP  - Neuvedeno
EP  - Neuvedeno
PB  - MDPI
SN  - 22237747
KW  - AChE
KW  - Amorpha fruticosa
KW  - BuChE
KW  - molecular docking
KW  - putrescine
KW  - spermidine
UR  - https://pubmed.ncbi.nlm.nih.gov/38732396/
N2  - Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
ER  -

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ and Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. \textit{PLANTS-BASEL}. BASEL: MDPI, 2024, vol.~13, No~9, p.~Neuvedeno, 10 pp. ISSN~2223-7747. Available from: https://dx.doi.org/10.3390/plants13091181.

Detailed Information on Publication Record