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@article{2407838, author = {Matušková, Veronika and Horňáčková, Pavla and Michalec, Marek and Zlámalíková, Lenka and Matulová, Květoslava and Uher, Michal}, article_location = {OLOMOUC}, doi = {http://dx.doi.org/10.5507/bp.2024.018}, keywords = {uveal melanoma; chromosome 6; chromosome 8; CISH, FISH; progression free survival}, language = {eng}, issn = {1213-8118}, journal = {Biomedical Papers}, title = {Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies}, url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672}, year = {2024} }
TY - JOUR ID - 2407838 AU - Matušková, Veronika - Horňáčková, Pavla - Michalec, Marek - Zlámalíková, Lenka - Matulová, Květoslava - Uher, Michal PY - 2024 TI - Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies JF - Biomedical Papers PB - PALACKY UNIV, MEDICAL FAC SN - 12138118 KW - uveal melanoma KW - chromosome 6 KW - chromosome 8 KW - CISH, FISH KW - progression free survival UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672 N2 - Background: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. Methods: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. Results: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. Conclusions: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations. ER -
MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Marek MICHALEC, Lenka ZLÁMALÍKOVÁ, Květoslava MATULOVÁ and Michal UHER. Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies. \textit{Biomedical Papers}. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2024. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2024.018.
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