Enhancing the utility of chromosome 6 and 8 testing in uveal
melanoma biopsies

J 2024

Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Marek MICHALEC, Lenka ZLÁMALÍKOVÁ, Květoslava MATULOVÁ et. al.

Basic information

Original name

Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies

Authors

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Marek MICHALEC, Lenka ZLÁMALÍKOVÁ, Květoslava MATULOVÁ and Michal UHER

Edition

Biomedical Papers, OLOMOUC, PALACKY UNIV, MEDICAL FAC, 2024, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.900 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2024.018

UT WoS

001238711300001

Keywords in English

uveal melanoma; chromosome 6; chromosome 8; CISH, FISH; progression free survival

Abstract

V originále

Background: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. Methods: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. Results: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. Conclusions: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations.

Citovat

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Marek MICHALEC, Lenka ZLÁMALÍKOVÁ, Květoslava MATULOVÁ and Michal UHER. Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies. Biomedical Papers. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2024. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2024.018.

@article{2407838,
   author = {Matušková, Veronika and Horňáčková, Pavla and Michalec, Marek and Zlámalíková, Lenka and Matulová, Květoslava and Uher, Michal},
   article_location = {OLOMOUC},
   doi = {http://dx.doi.org/10.5507/bp.2024.018},
   keywords = {uveal melanoma; chromosome 6; chromosome 8; CISH, FISH; progression free survival},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672},
   year = {2024}
}

TY  - JOUR
ID  - 2407838
AU  - Matušková, Veronika - Horňáčková, Pavla - Michalec, Marek - Zlámalíková, Lenka - Matulová, Květoslava - Uher, Michal
PY  - 2024
TI  - Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies
JF  - Biomedical Papers
PB  - PALACKY UNIV, MEDICAL FAC
SN  - 12138118
KW  - uveal melanoma
KW  - chromosome 6
KW  - chromosome 8
KW  - CISH, FISH
KW  - progression free survival
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672
N2  - Background: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. Methods: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. Results: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. Conclusions: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations.
ER  -

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Marek MICHALEC, Lenka ZLÁMALÍKOVÁ, Květoslava MATULOVÁ and Michal UHER. Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies. \textit{Biomedical Papers}. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2024. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2024.018.

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