Detailed Information on Publication Record
2024
A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children
JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ et. al.Basic information
Original name
A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children
Authors
JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA and Petr ŠTOURAČ
Edition
ROMANIAN JOURNAL OF INTERNAL MEDICINE, WARSAW, SCIENDO, 2024, 1582-3296
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.900 in 2022
Organization unit
Faculty of Medicine
UT WoS
001181323600001
Keywords in English
child; obesity; sepsis; genotype; genetic predisposition to the disease
Tags
International impact, Reviewed
Změněno: 2/7/2024 12:10, Mgr. Tereza Miškechová
Abstract
V originále
Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.