A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO)
Gene Is Associated with Sepsis Status in Children

J 2024

A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ et. al.

Basic information

Original name

A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children

Authors

Edition

ROMANIAN JOURNAL OF INTERNAL MEDICINE, WARSAW, SCIENDO, 2024, 1582-3296

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.900 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2478/rjim-2024-0008

UT WoS

001181323600001

Keywords in English

child; obesity; sepsis; genotype; genetic predisposition to the disease

Abstract

V originále

Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.

Citovat

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA and Petr ŠTOURAČ. A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children. ROMANIAN JOURNAL OF INTERNAL MEDICINE. WARSAW: SCIENDO, 2024, 18 pp. ISSN 1582-3296. Available from: https://dx.doi.org/10.2478/rjim-2024-0008.

@article{2407859,
   author = {Jabandžiev, Petr and Hubacek, Jaroslav Alois and Jaroslav, Michalek and Jouza, Martin and Papež, Jan and Pecl, Jakub and Slabá, Kateřina and Slabý, Ondřej and Urík, Milan and Aulická, Štefánia and Kunovský, Lumír and Jaroslav, Michalek and Dominik, Petr and Kratochvíl, Milan and Klučka, Jozef and Štourač, Petr},
   article_location = {WARSAW},
   doi = {http://dx.doi.org/10.2478/rjim-2024-0008},
   keywords = {child; obesity; sepsis; genotype; genetic predisposition to the disease},
   language = {eng},
   issn = {1582-3296},
   journal = {ROMANIAN JOURNAL OF INTERNAL MEDICINE},
   title = {A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children},
   url = {https://sciendo.com/article/10.2478/rjim-2024-0008},
   year = {2024}
}

TY  - JOUR
ID  - 2407859
AU  - Jabandžiev, Petr - Hubacek, Jaroslav Alois - Jaroslav, Michalek - Jouza, Martin - Papež, Jan - Pecl, Jakub - Slabá, Kateřina - Slabý, Ondřej - Urík, Milan - Aulická, Štefánia - Kunovský, Lumír - Jaroslav, Michalek - Dominik, Petr - Kratochvíl, Milan - Klučka, Jozef - Štourač, Petr
PY  - 2024
TI  - A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children
JF  - ROMANIAN JOURNAL OF INTERNAL MEDICINE
PB  - SCIENDO
SN  - 15823296
KW  - child
KW  - obesity
KW  - sepsis
KW  - genotype
KW  - genetic predisposition to the disease
UR  - https://sciendo.com/article/10.2478/rjim-2024-0008
N2  - Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.
ER  -

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA and Petr ŠTOURAČ. A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children. \textit{ROMANIAN JOURNAL OF INTERNAL MEDICINE}. WARSAW: SCIENDO, 2024, 18 pp. ISSN~1582-3296. Available from: https://dx.doi.org/10.2478/rjim-2024-0008.

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