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@article{2407859, author = {Jabandžiev, Petr and Hubacek, Jaroslav Alois and Jaroslav, Michalek and Jouza, Martin and Papež, Jan and Pecl, Jakub and Slabá, Kateřina and Slabý, Ondřej and Urík, Milan and Aulická, Štefánia and Kunovský, Lumír and Jaroslav, Michalek and Dominik, Petr and Kratochvíl, Milan and Klučka, Jozef and Štourač, Petr}, article_location = {WARSAW}, doi = {http://dx.doi.org/10.2478/rjim-2024-0008}, keywords = {child; obesity; sepsis; genotype; genetic predisposition to the disease}, language = {eng}, issn = {1582-3296}, journal = {ROMANIAN JOURNAL OF INTERNAL MEDICINE}, title = {A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children}, url = {https://sciendo.com/article/10.2478/rjim-2024-0008}, year = {2024} }
TY - JOUR ID - 2407859 AU - Jabandžiev, Petr - Hubacek, Jaroslav Alois - Jaroslav, Michalek - Jouza, Martin - Papež, Jan - Pecl, Jakub - Slabá, Kateřina - Slabý, Ondřej - Urík, Milan - Aulická, Štefánia - Kunovský, Lumír - Jaroslav, Michalek - Dominik, Petr - Kratochvíl, Milan - Klučka, Jozef - Štourač, Petr PY - 2024 TI - A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children JF - ROMANIAN JOURNAL OF INTERNAL MEDICINE PB - SCIENDO SN - 15823296 KW - child KW - obesity KW - sepsis KW - genotype KW - genetic predisposition to the disease UR - https://sciendo.com/article/10.2478/rjim-2024-0008 N2 - Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication. ER -
JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA and Petr ŠTOURAČ. A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children. \textit{ROMANIAN JOURNAL OF INTERNAL MEDICINE}. WARSAW: SCIENDO, 2024, 18 pp. ISSN~1582-3296. Available from: https://dx.doi.org/10.2478/rjim-2024-0008.
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