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@article{2409385,
author = {Matyasova, Katarina and Soltysova, Andrea and Babula, Petr and Križanová, Oľga and Liskova, Veronika},
article_location = {MUNICH},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.ejcb.2024.151415},
keywords = {mercaptopyruvate sulfurtransferase; Fission; Colon/colorectal cancer; Mitochondria},
language = {eng},
issn = {0171-9335},
journal = {European Journal of Cell Biology},
title = {Role of the 3-mercaptopyruvate sulfurtransferase in colon/ colorectal cancers},
url = {https://www.sciencedirect.com/science/article/pii/S0171933524000323?via%3Dihub},
volume = {103},
year = {2024}
}
TY - JOUR
ID - 2409385
AU - Matyasova, Katarina - Soltysova, Andrea - Babula, Petr - Križanová, Oľga - Liskova, Veronika
PY - 2024
TI - Role of the 3-mercaptopyruvate sulfurtransferase in colon/ colorectal cancers
JF - European Journal of Cell Biology
VL - 103
IS - 2
SP - 1-12
EP - 1-12
PB - ELSEVIER GMBH
SN - 01719335
KW - mercaptopyruvate sulfurtransferase
KW - Fission
KW - Colon/colorectal cancer
KW - Mitochondria
UR - https://www.sciencedirect.com/science/article/pii/S0171933524000323?via%3Dihub
N2 - The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now. Therefore, we focused on the determination of function of MPST in colon (HCT116 cells)/colorectal (DLD1 cells) cancers. In silico analysis revealed that in gastrointestinal cancers, MPST together with its binding partners can be either of a high risk or might have a protective effect. Silencing of MPST gene resulted in decreased ATP, while acetyl-CoA levels were elevated. Increased apoptosis was detected in cells with silenced MPST gene, which was accompanied by decrease in mitochondrial membrane potential, but no changes in IP3 receptor's protein. Mitochondria underwent activation of fission and elevated DRP1 expression after MPST silencing. Proliferation and migration of DLD1 and HCT116 cells were markedly affected, showing the importance of MPST protein in colon/colorectal cancer development.
ER -
MATYASOVA, Katarina, Andrea SOLTYSOVA, Petr BABULA, Oľga KRIŽANOVÁ and Veronika LISKOVA. Role of the 3-mercaptopyruvate sulfurtransferase in colon/ colorectal cancers. \textit{European Journal of Cell Biology}. MUNICH: ELSEVIER GMBH, 2024, vol.~103, No~2, p.~1-12. ISSN~0171-9335. Available from: https://dx.doi.org/10.1016/j.ejcb.2024.151415.
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