Rupture point is associated with divergent hemodynamics in intracranial aneurysms

@article{2409458,
   author = {Hejcl, Ales and Brunatova, Jana and Svihlova, Helena and Víteček, Jan and Vítečková Wünschová, Andrea and Sejkorova, Alena and Hundza Stratilova, Maria and Radovnicky, Tomas and Sames, Martin and Hron, Jaroslav},
   article_location = {Lausanne},
   article_number = {May 2024},
   doi = {http://dx.doi.org/10.3389/fneur.2024.1364105},
   keywords = {intracranial aneurysm; computational fluid dynamics; rupture; particle image velocimetry (PIV); wall shear stress (WSS)},
   language = {eng},
   issn = {1664-2295},
   journal = {Frontiers in Neurology},
   title = {Rupture point is associated with divergent hemodynamics in intracranial aneurysms},
   url = {https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1364105/full},
   volume = {15},
   year = {2024}
}

TY  - JOUR
ID  - 2409458
AU  - Hejcl, Ales - Brunatova, Jana - Svihlova, Helena - Víteček, Jan - Vítečková Wünschová, Andrea - Sejkorova, Alena - Hundza Stratilova, Maria - Radovnicky, Tomas - Sames, Martin - Hron, Jaroslav
PY  - 2024
TI  - Rupture point is associated with divergent hemodynamics in intracranial aneurysms
JF  - Frontiers in Neurology
VL  - 15
IS  - May 2024
SP  - 1-12
EP  - 1-12
PB  - Frontiers
SN  - 16642295
KW  - intracranial aneurysm
KW  - computational fluid dynamics
KW  - rupture
KW  - particle image velocimetry (PIV)
KW  - wall shear stress (WSS)
UR  - https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1364105/full
N2  - Background Understanding the risk factors leading to intracranial aneurysm (IA) rupture have still not been fully clarified. They are vital for proper medical guidance of patients harboring unruptured IAs. Clarifying the hemodynamics associated with the point of rupture could help could provide useful information about some of the risk factors. Thus far, few studies have studied this issue with often diverging conclusions.Methods We identified a point of rupture in patients operated for an IAs during surgery, using a combination of preoperative computed tomography (CT) and computed tomography angiography (CTA). Hemodynamic parameters were calculated both for the aneurysm sac as a whole and the point of rupture. In two cases, the results of CFD were compared with those of the experiment using particle image velocimetry (PIV).Results We were able to identify 6 aneurysms with a well-demarcated point of rupture. In four aneurysms, the rupture point was near the vortex with low wall shear stress (WSS) and high oscillatory shear index (OSI). In one case, the rupture point was in the flow jet with high WSS. In the last case, the rupture point was in the significant bleb and no specific hemodynamic parameters were found. The CFD results were verified in the PIV part of the study.Conclusion Our study shows that different hemodynamic scenarios are associated with the site of IA rupture. The numerical simulations were confirmed by laboratory models. This study further supports the hypothesis that various pathological pathways may lead to aneurysm wall damage resulting in its rupture.
ER  - 

HEJCL, Ales, Jana BRUNATOVA, Helena SVIHLOVA, Jan VÍTEČEK, Andrea VÍTEČKOVÁ WÜNSCHOVÁ, Alena SEJKOROVA, Maria HUNDZA STRATILOVA, Tomas RADOVNICKY, Martin SAMES and Jaroslav HRON. Rupture point is associated with divergent hemodynamics in intracranial aneurysms. \textit{Frontiers in Neurology}. Lausanne: Frontiers, 2024, vol.~15, May 2024, p.~1-12. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2024.1364105.