J 2024

Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies

MAKOVSKI, Tatjana T, Jinane GHATTAS, Stephanie MONNIER-BESNARD, Lisa CAVILLOT, Monika AMBROŽOVÁ et. al.

Basic information

Original name

Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies

Authors

MAKOVSKI, Tatjana T, Jinane GHATTAS, Stephanie MONNIER-BESNARD, Lisa CAVILLOT, Monika AMBROŽOVÁ (203 Czech Republic, belonging to the institution), Barbora VASINOVA (203 Czech Republic), Rodrigo FETEIRA-SANTOS, Peter BEZZEGH, Felipe Ponce BOLLMANN, James COTTAM, Romana HANEEF, Brecht DEVLEESSCHAUWER, Niko SPEYBROECK, Paulo Jorge NOGUEIRA, Maria Joao FORJAZ, Joel COSTE and Laure CARCAILLON-BENTATA

Edition

AGING CLINICAL AND EXPERIMENTAL RESEARCH, NEW YORK, SPRINGER, 2024, 1594-0667

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.000 in 2022

Organization unit

Faculty of Medicine

UT WoS

001161688700002

Keywords in English

COVID-19; SARS-CoV-2; Multimorbidity; Multiple chronic conditions; Frailty

Tags

Tags

International impact, Reviewed
Změněno: 10/6/2024 12:18, Mgr. Tereza Miškechová

Abstract

V originále

BackgroundEstimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444.MethodsPubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered.ResultsOverall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level.DiscussionFuture studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.