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@article{2409518,
author = {Mayerova, Lucie and Wohlfahrt, Peter and Sonka, Milan and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Karmazin, Vladimir and Malek, Ivan and Bedanova, Helena and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Kovarnik, Tomas and Pazdernik, Michal},
article_location = {HOBOKEN},
article_number = {3},
doi = {http://dx.doi.org/10.1111/ctr.15275},
keywords = {acetylsalicylic acid; cardiac allograft vasculopathy; lipid plaque; OCT},
language = {eng},
issn = {0902-0063},
journal = {CLINICAL TRANSPLANTATION},
title = {Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis},
url = {https://onlinelibrary.wiley.com/doi/10.1111/ctr.15275},
volume = {38},
year = {2024}
}
TY - JOUR
ID - 2409518
AU - Mayerova, Lucie - Wohlfahrt, Peter - Sonka, Milan - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Karmazin, Vladimir - Malek, Ivan - Bedanova, Helena - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Kovarnik, Tomas - Pazdernik, Michal
PY - 2024
TI - Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis
JF - CLINICAL TRANSPLANTATION
VL - 38
IS - 3
SP - 1-11
EP - 1-11
PB - WILEY
SN - 09020063
KW - acetylsalicylic acid
KW - cardiac allograft vasculopathy
KW - lipid plaque
KW - OCT
UR - https://onlinelibrary.wiley.com/doi/10.1111/ctr.15275
N2 - BackgroundThere is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV).MethodsA nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors.ResultsIn total, 175 patients (mean age 52 +/- 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699)ConclusionThis study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.
ER -
MAYEROVA, Lucie, Peter WOHLFAHRT, Milan SONKA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Helena BEDANOVA, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK and Michal PAZDERNIK. Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis. \textit{CLINICAL TRANSPLANTATION}. HOBOKEN: WILEY, 2024, vol.~38, No~3, p.~1-11. ISSN~0902-0063. Available from: https://dx.doi.org/10.1111/ctr.15275.
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