Acetylsalicylic acid use and development of cardiac allograft
vasculopathy: A national prospective study using highly
automated 3-D optical coherence tomography analysis

J 2024

Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis

MAYEROVA, Lucie, Peter WOHLFAHRT, Milan SONKA, Zhi CHEN, Josef KAUTZNER et. al.

Basic information

Original name

Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis

Authors

MAYEROVA, Lucie (203 Czech Republic), Peter WOHLFAHRT (203 Czech Republic), Milan SONKA (203 Czech Republic), Zhi CHEN, Josef KAUTZNER (203 Czech Republic), Vojtech MELENOVSKY (203 Czech Republic), Vladimir KARMAZIN (203 Czech Republic), Ivan MALEK (203 Czech Republic), Helena BEDANOVA (203 Czech Republic), Ales TOMASEK (203 Czech Republic), Eva OZÁBALOVÁ (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Tomas KOVARNIK (203 Czech Republic) and Michal PAZDERNIK (203 Czech Republic)

Edition

CLINICAL TRANSPLANTATION, HOBOKEN, WILEY, 2024, 0902-0063

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.100 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/ctr.15275

UT WoS

001183729600001

Keywords in English

acetylsalicylic acid; cardiac allograft vasculopathy; lipid plaque; OCT

Abstract

V originále

BackgroundThere is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV).MethodsA nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors.ResultsIn total, 175 patients (mean age 52 +/- 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699)ConclusionThis study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.

Citovat

MAYEROVA, Lucie, Peter WOHLFAHRT, Milan SONKA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Helena BEDANOVA, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK and Michal PAZDERNIK. Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis. CLINICAL TRANSPLANTATION. HOBOKEN: WILEY, 2024, vol. 38, No 3, p. 1-11. ISSN 0902-0063. Available from: https://dx.doi.org/10.1111/ctr.15275.

@article{2409518,
   author = {Mayerova, Lucie and Wohlfahrt, Peter and Sonka, Milan and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Karmazin, Vladimir and Malek, Ivan and Bedanova, Helena and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Kovarnik, Tomas and Pazdernik, Michal},
   article_location = {HOBOKEN},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/ctr.15275},
   keywords = {acetylsalicylic acid; cardiac allograft vasculopathy; lipid plaque; OCT},
   language = {eng},
   issn = {0902-0063},
   journal = {CLINICAL TRANSPLANTATION},
   title = {Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/ctr.15275},
   volume = {38},
   year = {2024}
}

TY  - JOUR
ID  - 2409518
AU  - Mayerova, Lucie - Wohlfahrt, Peter - Sonka, Milan - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Karmazin, Vladimir - Malek, Ivan - Bedanova, Helena - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Kovarnik, Tomas - Pazdernik, Michal
PY  - 2024
TI  - Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis
JF  - CLINICAL TRANSPLANTATION
VL  - 38
IS  - 3
SP  - 1-11
EP  - 1-11
PB  - WILEY
SN  - 09020063
KW  - acetylsalicylic acid
KW  - cardiac allograft vasculopathy
KW  - lipid plaque
KW  - OCT
UR  - https://onlinelibrary.wiley.com/doi/10.1111/ctr.15275
N2  - BackgroundThere is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV).MethodsA nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors.ResultsIn total, 175 patients (mean age 52 +/- 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699)ConclusionThis study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.
ER  -

MAYEROVA, Lucie, Peter WOHLFAHRT, Milan SONKA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Helena BEDANOVA, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK and Michal PAZDERNIK. Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis. \textit{CLINICAL TRANSPLANTATION}. HOBOKEN: WILEY, 2024, vol.~38, No~3, p.~1-11. ISSN~0902-0063. Available from: https://dx.doi.org/10.1111/ctr.15275.

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