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@article{2409560,
author = {Pindjakova, Dominika and Mascaretti, Sarka and Hricoviniova, Jana and Hosek, Jan and Gregorová, Jana and Kos, Jiří and Cizek, Alois and Hricoviniova, Zuzana and Jampilek, Josef},
article_location = {OXFORD},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.heliyon.2024.e29051},
keywords = {Quinazolinones; Schiff bases; Cu(II) complexes; Antibacterial activity; Antibiofilm effect; Cytotoxicity},
language = {eng},
issn = {2405-8440},
journal = {Heliyon},
title = {Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes},
url = {https://www.sciencedirect.com/science/article/pii/S2405844024050825?via%3Dihub},
volume = {10},
year = {2024}
}
TY - JOUR
ID - 2409560
AU - Pindjakova, Dominika - Mascaretti, Sarka - Hricoviniova, Jana - Hosek, Jan - Gregorová, Jana - Kos, Jiří - Cizek, Alois - Hricoviniova, Zuzana - Jampilek, Josef
PY - 2024
TI - Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes
JF - Heliyon
VL - 10
IS - 7
SP - 1-10
EP - 1-10
PB - ELSEVIER
SN - 24058440
KW - Quinazolinones
KW - Schiff bases
KW - Cu(II) complexes
KW - Antibacterial activity
KW - Antibiofilm effect
KW - Cytotoxicity
UR - https://www.sciencedirect.com/science/article/pii/S2405844024050825?via%3Dihub
N2 - A series of nine 2,3-disubstituted-quinazolin-4(3 H )-one derived Schiff bases and their three Cu(II) complexes was prepared and tested for their antimicrobial activities against reference strains Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 and resistant clinical isolates of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). All the substances were tested in vitro against Mycobacterium tuberculosis H 37 Ra ATCC 25177, M. kansasii DSM 44162 and M. smegmatis ATCC 700084. While anti-enterococcal and antimycobacterial activities were insignificant, 3-[( E )-(2-hydroxy-5-nitrobenzylidene)amino]-2-(2- hydroxy-5-nitrophenyl)-2,3-dihydroquinazolin-4(1 H )-one ( SB3 ) and its Cu(II) complex ( SB3 -Cu ) demonstrated bacteriostatic antistaphylococcal activity. In addition, both compounds, as well as the other two prepared complexes, showed antibiofilm activity, which resulted in a reduction of biofilm formation and eradication of mature S. aureus biofilm by 80% even at concentrations lower than the values of their minimum inhibitory concentrations. In addition, the compounds were tested for their cytotoxic effect on the human monocytic leukemia cell line THP-1. The antileukemic efficiency was improved by the preparation of Cu(II) complexes from the corresponding non-chelated Schiff base ligands.
ER -
PINDJAKOVA, Dominika, Sarka MASCARETTI, Jana HRICOVINIOVA, Jan HOSEK, Jana GREGOROVÁ, Jiří KOS, Alois CIZEK, Zuzana HRICOVINIOVA and Josef JAMPILEK. Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes. \textit{Heliyon}. OXFORD: ELSEVIER, 2024, vol.~10, No~7, p.~1-10. ISSN~2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2024.e29051.
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