Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey
Authors
LAHMER, Tobias, Jon SALMANTON-GARCIA, Francesco MARCHESI, Shaimaa EL-ASHWAH, Marcio NUCCI, Caroline BESSON, Federico ITRI, Ozren JAKSIC, Natasha COLOVIC, Barbora WEINBERGEROVÁ (203 Czech Republic, belonging to the institution), Guldane Cengiz SEVAL, Tatjana ADZIC-VUKICEVIC, Tomas SZOTKOWSKI, Uluhan SILI, Michelina DARGENIO, van Praet JENS, van Doesum JAAP, Martin SCHOENLEIN, Zdenek RACIL, Pavel ZAK, Christian Bjorn POULSEN, Gabriele MAGLIANO, Moraima JIMENEZ, Valentina BONUOMO, Klara PIUKOVICS, Giulia DRAGONETTI, Fatih DEMIRKAN, Ola BLENNOW, Toni VALKOVIC, Da Silva Maria GOMES, Johan MAERTENS, Andreas GLENTHOJ, Noemi FERNANDEZ, Rui BERGANTIM, Luisa VERGA, Verena PETZER, Ali S OMRANI, Gustavo-Adolfo MENDEZ, Marina MACHADO, Marie-Pierre LEDOUX, Rebeca BAILEN, Rafael F DUARTE, Del Principe Maria ILARIA, Francesca FARINA, Sonia MARTIN-PEREZ, Julio DAVILA-VALLS, Monia MARCHETTI, Yavuz M BILGIN, Nicola S FRACCHIOLLA, Chiara CATTANEO, Ildefonso ESPIGADO, Raul CORDOBA, Graham P COLLINS, Jorge LABRADOR, Iker FALCES-ROMERO, Lucia PREZIOSO, Stef MEERS, Francesco PASSAMONTI, Caterina BUQUICCHIO, Alberto LOPEZ-GARCIA, Austin KULASEKARARAJ, Irati ORMAZABAL-VELEZ, Annarosa CUCCARO, Carolina GARCIA-VIDAL, Alessandro BUSCA, Milan NAVRATIL, de Jonge NICK, Monika M BIERNAT, Anna GUIDETTI, Ghaith ABU-ZEINAH, Michail SAMARKOS, Amalia ANASTASOPOULOU, de Ramon CRISTINA, Tomas Jose GONZALEZ-LOPEZ, Martin HOENIGL, Olimpia FINIZIO, Laszlo Imre PINCZES, Natasha ALI, Antonio VENA, Carlo TASCINI, Zlate STOJANOSKI, Maria MERELLI, Ziad EMARAH, Milena KOHN, Aleksandra BARAC, Milos MLADENOVIC, Bojana MISKOVIC, Osman ILHAN, Gokce Melis COLAK, Martin CERNAN, Stefanie K GRAEFE, Emanuele AMMATUNA, Michaela HANAKOVA, Benjamin VISEK, Alba CABIRTA, Anna NORDLANDER, Raquel Nunes RODRIGUES, Ditte Stampe HERSBY, Giovanni Paolo Maria ZAMBROTTA, Dominik WOLF, Lucia NUNEZ-MARTIN-BUITRAGO, Elena ARELLANO, Francesco Aiello TOMMASO, Ramon GARCIA-SANZ, Juergen PRATTES, Matthias EGGER, Alessandro LIMONGELLI, Martina BAVASTRO, Milche CVETANOSKI, Miriam DIBOS, Sebastian RASCH, Laman RAHIMLI, Oliver A CORNELY and Livio PAGANO
The risk for a severe coronavirus disease 2019 (COVID-19) with need for an intensive care unit (ICU) admission in a non-immunocompromised vaccinated population dropped from 5% at the beginning of the pandemic to at least 0.2% and is still decreasing since the omicron strain dominates the COVID-19 pandemic [1]. Beyond the risk factors identified for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection like male sex, older age, and comorbidities such as cardiovascular disease, lung disease or obesity, patients with a history of malignancy, specifically patients with haematological malignancy, are prone to develop a complicated SARS-CoV-2 infection with need for ICU which is still associated with poorer clinical outcome. The circumstances of a widely heterogenous population with regards to the type of haematological malignancy, extent of disease, haematological malignancy treatment history, and baseline performance status are even more challenging in the environment of an ICU. Although, data referring to critically ill COVID-19 patients regarding treatment strategies and outcome are widely available, data referring to critically ill patients with haematological malignancy are scarce and underreported. The aim of this study is to analyze the epidemiology, risk factors and outcome of patients with haematological malignancy with need for an ICU setting using the data from the large-scale EPICOVIDEHA registry of the European Hematology Association—Scientific Working Group Infectious in Hematology (EHA-SWG).
LAHMER, Tobias, Jon SALMANTON-GARCIA, Francesco MARCHESI, Shaimaa EL-ASHWAH, Marcio NUCCI, Caroline BESSON, Federico ITRI, Ozren JAKSIC, Natasha COLOVIC, Barbora WEINBERGEROVÁ, Guldane Cengiz SEVAL, Tatjana ADZIC-VUKICEVIC, Tomas SZOTKOWSKI, Uluhan SILI, Michelina DARGENIO, van Praet JENS, van Doesum JAAP, Martin SCHOENLEIN, Zdenek RACIL, Pavel ZAK, Christian Bjorn POULSEN, Gabriele MAGLIANO, Moraima JIMENEZ, Valentina BONUOMO, Klara PIUKOVICS, Giulia DRAGONETTI, Fatih DEMIRKAN, Ola BLENNOW, Toni VALKOVIC, Da Silva Maria GOMES, Johan MAERTENS, Andreas GLENTHOJ, Noemi FERNANDEZ, Rui BERGANTIM, Luisa VERGA, Verena PETZER, Ali S OMRANI, Gustavo-Adolfo MENDEZ, Marina MACHADO, Marie-Pierre LEDOUX, Rebeca BAILEN, Rafael F DUARTE, Del Principe Maria ILARIA, Francesca FARINA, Sonia MARTIN-PEREZ, Julio DAVILA-VALLS, Monia MARCHETTI, Yavuz M BILGIN, Nicola S FRACCHIOLLA, Chiara CATTANEO, Ildefonso ESPIGADO, Raul CORDOBA, Graham P COLLINS, Jorge LABRADOR, Iker FALCES-ROMERO, Lucia PREZIOSO, Stef MEERS, Francesco PASSAMONTI, Caterina BUQUICCHIO, Alberto LOPEZ-GARCIA, Austin KULASEKARARAJ, Irati ORMAZABAL-VELEZ, Annarosa CUCCARO, Carolina GARCIA-VIDAL, Alessandro BUSCA, Milan NAVRATIL, de Jonge NICK, Monika M BIERNAT, Anna GUIDETTI, Ghaith ABU-ZEINAH, Michail SAMARKOS, Amalia ANASTASOPOULOU, de Ramon CRISTINA, Tomas Jose GONZALEZ-LOPEZ, Martin HOENIGL, Olimpia FINIZIO, Laszlo Imre PINCZES, Natasha ALI, Antonio VENA, Carlo TASCINI, Zlate STOJANOSKI, Maria MERELLI, Ziad EMARAH, Milena KOHN, Aleksandra BARAC, Milos MLADENOVIC, Bojana MISKOVIC, Osman ILHAN, Gokce Melis COLAK, Martin CERNAN, Stefanie K GRAEFE, Emanuele AMMATUNA, Michaela HANAKOVA, Benjamin VISEK, Alba CABIRTA, Anna NORDLANDER, Raquel Nunes RODRIGUES, Ditte Stampe HERSBY, Giovanni Paolo Maria ZAMBROTTA, Dominik WOLF, Lucia NUNEZ-MARTIN-BUITRAGO, Elena ARELLANO, Francesco Aiello TOMMASO, Ramon GARCIA-SANZ, Juergen PRATTES, Matthias EGGER, Alessandro LIMONGELLI, Martina BAVASTRO, Milche CVETANOSKI, Miriam DIBOS, Sebastian RASCH, Laman RAHIMLI, Oliver A CORNELY and Livio PAGANO. Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey. Infection. HEIDELBERG: Springer, 2024, vol. 52, No 3, p. 1125-1141. ISSN 0300-8126. Available from: https://dx.doi.org/10.1007/s15010-023-02169-7.
@article{2409570, author = {Lahmer, Tobias and SalmantonandGarcia, Jon and Marchesi, Francesco and ElandAshwah, Shaimaa and Nucci, Marcio and Besson, Caroline and Itri, Federico and Jaksic, Ozren and Colovic, Natasha and Weinbergerová, Barbora and Seval, Guldane Cengiz and AdzicandVukicevic, Tatjana and Szotkowski, Tomas and Sili, Uluhan and Dargenio, Michelina and Jens, van Praet and Jaap, van Doesum and Schoenlein, Martin and Racil, Zdenek and Zak, Pavel and Poulsen, Christian Bjorn and Magliano, Gabriele and Jimenez, Moraima and Bonuomo, Valentina and Piukovics, Klara and Dragonetti, Giulia and Demirkan, Fatih and Blennow, Ola and Valkovic, Toni and Gomes, Da Silva Maria and Maertens, Johan and Glenthoj, Andreas and Fernandez, Noemi and Bergantim, Rui and Verga, Luisa and Petzer, Verena and Omrani, Ali S and Mendez, GustavoandAdolfo and Machado, Marina and Ledoux, MarieandPierre and Bailen, Rebeca and Duarte, Rafael F and Ilaria, Del Principe Maria and Farina, Francesca and MartinandPerez, Sonia and DavilaandValls, Julio and Marchetti, Monia and Bilgin, Yavuz M and Fracchiolla, Nicola S and Cattaneo, Chiara and Espigado, Ildefonso and Cordoba, Raul and Collins, Graham P and Labrador, Jorge and FalcesandRomero, Iker and Prezioso, Lucia and Meers, Stef and Passamonti, Francesco and Buquicchio, Caterina and LopezandGarcia, Alberto and Kulasekararaj, Austin and OrmazabalandVelez, Irati and Cuccaro, Annarosa and GarciaandVidal, Carolina and Busca, Alessandro and Navratil, Milan and Nick, de Jonge and Biernat, Monika M and Guidetti, Anna and AbuandZeinah, Ghaith and Samarkos, Michail and Anastasopoulou, Amalia and Cristina, de Ramon and GonzalezandLopez, Tomas Jose and Hoenigl, Martin and Finizio, Olimpia and Pinczes, Laszlo Imre and Ali, Natasha and Vena, Antonio and Tascini, Carlo and Stojanoski, Zlate and Merelli, Maria and Emarah, Ziad and Kohn, Milena and Barac, Aleksandra and Mladenovic, Milos and Miskovic, Bojana and Ilhan, Osman and Colak, Gokce Melis and Cernan, Martin and Graefe, Stefanie K and Ammatuna, Emanuele and Hanakova, Michaela and Visek, Benjamin and Cabirta, Alba and Nordlander, Anna and Rodrigues, Raquel Nunes and Hersby, Ditte Stampe and Zambrotta, Giovanni Paolo Maria and Wolf, Dominik and NunezandMartinandBuitrago, Lucia and Arellano, Elena and Tommaso, Francesco Aiello and GarciaandSanz, Ramon and Prattes, Juergen and Egger, Matthias and Limongelli, Alessandro and Bavastro, Martina and Cvetanoski, Milche and Dibos, Miriam and Rasch, Sebastian and Rahimli, Laman and Cornely, Oliver A and Pagano, Livio}, article_location = {HEIDELBERG}, article_number = {3}, doi = {http://dx.doi.org/10.1007/s15010-023-02169-7}, keywords = {COVID-19; haematological malignancies}, language = {eng}, issn = {0300-8126}, journal = {Infection}, title = {Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey}, url = {https://link.springer.com/article/10.1007/s15010-023-02169-7}, volume = {52}, year = {2024} }
TY - JOUR ID - 2409570 AU - Lahmer, Tobias - Salmanton-Garcia, Jon - Marchesi, Francesco - El-Ashwah, Shaimaa - Nucci, Marcio - Besson, Caroline - Itri, Federico - Jaksic, Ozren - Colovic, Natasha - Weinbergerová, Barbora - Seval, Guldane Cengiz - Adzic-Vukicevic, Tatjana - Szotkowski, Tomas - Sili, Uluhan - Dargenio, Michelina - Jens, van Praet - Jaap, van Doesum - Schoenlein, Martin - Racil, Zdenek - Zak, Pavel - Poulsen, Christian Bjorn - Magliano, Gabriele - Jimenez, Moraima - Bonuomo, Valentina - Piukovics, Klara - Dragonetti, Giulia - Demirkan, Fatih - Blennow, Ola - Valkovic, Toni - Gomes, Da Silva Maria - Maertens, Johan - Glenthoj, Andreas - Fernandez, Noemi - Bergantim, Rui - Verga, Luisa - Petzer, Verena - Omrani, Ali S - Mendez, Gustavo-Adolfo - Machado, Marina - Ledoux, Marie-Pierre - Bailen, Rebeca - Duarte, Rafael F - Ilaria, Del Principe Maria - Farina, Francesca - Martin-Perez, Sonia - Davila-Valls, Julio - Marchetti, Monia - Bilgin, Yavuz M - Fracchiolla, Nicola S - Cattaneo, Chiara - Espigado, Ildefonso - Cordoba, Raul - Collins, Graham P - Labrador, Jorge - Falces-Romero, Iker - Prezioso, Lucia - Meers, Stef - Passamonti, Francesco - Buquicchio, Caterina - Lopez-Garcia, Alberto - Kulasekararaj, Austin - Ormazabal-Velez, Irati - Cuccaro, Annarosa - Garcia-Vidal, Carolina - Busca, Alessandro - Navratil, Milan - Nick, de Jonge - Biernat, Monika M - Guidetti, Anna - Abu-Zeinah, Ghaith - Samarkos, Michail - Anastasopoulou, Amalia - Cristina, de Ramon - Gonzalez-Lopez, Tomas Jose - Hoenigl, Martin - Finizio, Olimpia - Pinczes, Laszlo Imre - Ali, Natasha - Vena, Antonio - Tascini, Carlo - Stojanoski, Zlate - Merelli, Maria - Emarah, Ziad - Kohn, Milena - Barac, Aleksandra - Mladenovic, Milos - Miskovic, Bojana - Ilhan, Osman - Colak, Gokce Melis - Cernan, Martin - Graefe, Stefanie K - Ammatuna, Emanuele - Hanakova, Michaela - Visek, Benjamin - Cabirta, Alba - Nordlander, Anna - Rodrigues, Raquel Nunes - Hersby, Ditte Stampe - Zambrotta, Giovanni Paolo Maria - Wolf, Dominik - Nunez-Martin-Buitrago, Lucia - Arellano, Elena - Tommaso, Francesco Aiello - Garcia-Sanz, Ramon - Prattes, Juergen - Egger, Matthias - Limongelli, Alessandro - Bavastro, Martina - Cvetanoski, Milche - Dibos, Miriam - Rasch, Sebastian - Rahimli, Laman - Cornely, Oliver A - Pagano, Livio PY - 2024 TI - Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey JF - Infection VL - 52 IS - 3 SP - 1125-1141 EP - 1125-1141 PB - Springer SN - 03008126 KW - COVID-19 KW - haematological malignancies UR - https://link.springer.com/article/10.1007/s15010-023-02169-7 N2 - The risk for a severe coronavirus disease 2019 (COVID-19) with need for an intensive care unit (ICU) admission in a non-immunocompromised vaccinated population dropped from 5% at the beginning of the pandemic to at least 0.2% and is still decreasing since the omicron strain dominates the COVID-19 pandemic [1]. Beyond the risk factors identified for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection like male sex, older age, and comorbidities such as cardiovascular disease, lung disease or obesity, patients with a history of malignancy, specifically patients with haematological malignancy, are prone to develop a complicated SARS-CoV-2 infection with need for ICU which is still associated with poorer clinical outcome. The circumstances of a widely heterogenous population with regards to the type of haematological malignancy, extent of disease, haematological malignancy treatment history, and baseline performance status are even more challenging in the environment of an ICU. Although, data referring to critically ill COVID-19 patients regarding treatment strategies and outcome are widely available, data referring to critically ill patients with haematological malignancy are scarce and underreported. The aim of this study is to analyze the epidemiology, risk factors and outcome of patients with haematological malignancy with need for an ICU setting using the data from the large-scale EPICOVIDEHA registry of the European Hematology Association—Scientific Working Group Infectious in Hematology (EHA-SWG). ER -
LAHMER, Tobias, Jon SALMANTON-GARCIA, Francesco MARCHESI, Shaimaa EL-ASHWAH, Marcio NUCCI, Caroline BESSON, Federico ITRI, Ozren JAKSIC, Natasha COLOVIC, Barbora WEINBERGEROVÁ, Guldane Cengiz SEVAL, Tatjana ADZIC-VUKICEVIC, Tomas SZOTKOWSKI, Uluhan SILI, Michelina DARGENIO, van Praet JENS, van Doesum JAAP, Martin SCHOENLEIN, Zdenek RACIL, Pavel ZAK, Christian Bjorn POULSEN, Gabriele MAGLIANO, Moraima JIMENEZ, Valentina BONUOMO, Klara PIUKOVICS, Giulia DRAGONETTI, Fatih DEMIRKAN, Ola BLENNOW, Toni VALKOVIC, Da Silva Maria GOMES, Johan MAERTENS, Andreas GLENTHOJ, Noemi FERNANDEZ, Rui BERGANTIM, Luisa VERGA, Verena PETZER, Ali S OMRANI, Gustavo-Adolfo MENDEZ, Marina MACHADO, Marie-Pierre LEDOUX, Rebeca BAILEN, Rafael F DUARTE, Del Principe Maria ILARIA, Francesca FARINA, Sonia MARTIN-PEREZ, Julio DAVILA-VALLS, Monia MARCHETTI, Yavuz M BILGIN, Nicola S FRACCHIOLLA, Chiara CATTANEO, Ildefonso ESPIGADO, Raul CORDOBA, Graham P COLLINS, Jorge LABRADOR, Iker FALCES-ROMERO, Lucia PREZIOSO, Stef MEERS, Francesco PASSAMONTI, Caterina BUQUICCHIO, Alberto LOPEZ-GARCIA, Austin KULASEKARARAJ, Irati ORMAZABAL-VELEZ, Annarosa CUCCARO, Carolina GARCIA-VIDAL, Alessandro BUSCA, Milan NAVRATIL, de Jonge NICK, Monika M BIERNAT, Anna GUIDETTI, Ghaith ABU-ZEINAH, Michail SAMARKOS, Amalia ANASTASOPOULOU, de Ramon CRISTINA, Tomas Jose GONZALEZ-LOPEZ, Martin HOENIGL, Olimpia FINIZIO, Laszlo Imre PINCZES, Natasha ALI, Antonio VENA, Carlo TASCINI, Zlate STOJANOSKI, Maria MERELLI, Ziad EMARAH, Milena KOHN, Aleksandra BARAC, Milos MLADENOVIC, Bojana MISKOVIC, Osman ILHAN, Gokce Melis COLAK, Martin CERNAN, Stefanie K GRAEFE, Emanuele AMMATUNA, Michaela HANAKOVA, Benjamin VISEK, Alba CABIRTA, Anna NORDLANDER, Raquel Nunes RODRIGUES, Ditte Stampe HERSBY, Giovanni Paolo Maria ZAMBROTTA, Dominik WOLF, Lucia NUNEZ-MARTIN-BUITRAGO, Elena ARELLANO, Francesco Aiello TOMMASO, Ramon GARCIA-SANZ, Juergen PRATTES, Matthias EGGER, Alessandro LIMONGELLI, Martina BAVASTRO, Milche CVETANOSKI, Miriam DIBOS, Sebastian RASCH, Laman RAHIMLI, Oliver A CORNELY and Livio PAGANO. Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey. \textit{Infection}. HEIDELBERG: Springer, 2024, vol.~52, No~3, p.~1125-1141. ISSN~0300-8126. Available from: https://dx.doi.org/10.1007/s15010-023-02169-7.