Controversies in neuro-oncology: Focal proton versus photon
radiation therapy for adult brain tumors

J 2024

Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors

EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA et. al.

Basic information

Original name

Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors

Authors

EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH and Giuseppe MINNITI

Edition

NEURO-ONCOLOGY PRACTICE, OXFORD, OXFORD UNIV PRESS, 2024, 2054-2577

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/nop/npae040

UT WoS

001234931700001

Keywords in English

brain tumors; chordomas; gliomas; meningiomas; proton beam; radiotherapy; radiosurgery

Abstract

V originále

Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.

Citovat

EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH and Giuseppe MINNITI. Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors. NEURO-ONCOLOGY PRACTICE. OXFORD: OXFORD UNIV PRESS, 2024, 14 pp. ISSN 2054-2577. Available from: https://dx.doi.org/10.1093/nop/npae040.

@article{2409580,
   author = {Eekers, Danielle B P and Zegers, Catharina M L and Ahmed, Kamran A and Amelio, Dante and Gupta, Tejpal and Harrabi, Semi Ben and Kazda, Tomáš and Scartoni, Daniele and Seidel, Clemens and Shih, Helen A and Minniti, Giuseppe},
   article_location = {OXFORD},
   doi = {http://dx.doi.org/10.1093/nop/npae040},
   keywords = {brain tumors; chordomas; gliomas; meningiomas; proton beam; radiotherapy; radiosurgery},
   language = {eng},
   issn = {2054-2577},
   journal = {NEURO-ONCOLOGY PRACTICE},
   title = {Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors},
   url = {https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npae040/7659617?login=true},
   year = {2024}
}

TY  - JOUR
ID  - 2409580
AU  - Eekers, Danielle B P - Zegers, Catharina M L - Ahmed, Kamran A - Amelio, Dante - Gupta, Tejpal - Harrabi, Semi Ben - Kazda, Tomáš - Scartoni, Daniele - Seidel, Clemens - Shih, Helen A - Minniti, Giuseppe
PY  - 2024
TI  - Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors
JF  - NEURO-ONCOLOGY PRACTICE
PB  - OXFORD UNIV PRESS
SN  - 20542577
KW  - brain tumors
KW  - chordomas
KW  - gliomas
KW  - meningiomas
KW  - proton beam
KW  - radiotherapy
KW  - radiosurgery
UR  - https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npae040/7659617?login=true
N2  - Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.
ER  -

EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH and Giuseppe MINNITI. Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors. \textit{NEURO-ONCOLOGY PRACTICE}. OXFORD: OXFORD UNIV PRESS, 2024, 14 pp. ISSN~2054-2577. Available from: https://dx.doi.org/10.1093/nop/npae040.

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