EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH and Giuseppe MINNITI. Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors. NEURO-ONCOLOGY PRACTICE. OXFORD: OXFORD UNIV PRESS, 2024, 14 pp. ISSN 2054-2577. Available from: https://dx.doi.org/10.1093/nop/npae040.
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Basic information
Original name Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors
Authors EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH and Giuseppe MINNITI.
Edition NEURO-ONCOLOGY PRACTICE, OXFORD, OXFORD UNIV PRESS, 2024, 2054-2577.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.700 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/nop/npae040
UT WoS 001234931700001
Keywords in English brain tumors; chordomas; gliomas; meningiomas; proton beam; radiotherapy; radiosurgery
Tags 14110812
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 10/6/2024 15:01.
Abstract
Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.
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