Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as
Methotrexate Carriers

J 2019

Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers

MIERZWA, Monika, Adrianna CYTRYNIAK, Pawel KRYSINSKI and Renata BILEWICZ

Basic information

Original name

Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers

Authors

MIERZWA, Monika, Adrianna CYTRYNIAK, Pawel KRYSINSKI and Renata BILEWICZ

Edition

Nanomaterials, BASEL, MDPI, 2019, 2079-4991

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

21000 2.10 Nano-technology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.324

DOI

http://dx.doi.org/10.3390/nano9040636

UT WoS

000467768800152

Keywords in English

methotrexate; cubic phase; magnetocubosomes; monoolein; liquid crystalline phase; drug delivery system; alternating magnetic field

Abstract

V originále

The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution.

Links

90127, large research infrastructures

Name: CIISB II

Citovat

MIERZWA, Monika, Adrianna CYTRYNIAK, Pawel KRYSINSKI and Renata BILEWICZ. Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers. Nanomaterials. BASEL: MDPI, 2019, vol. 9, No 4, p. 1-17. ISSN 2079-4991. Available from: https://dx.doi.org/10.3390/nano9040636.

@article{2409802,
   author = {Mierzwa, Monika and Cytryniak, Adrianna and Krysinski, Pawel and Bilewicz, Renata},
   article_location = {BASEL},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/nano9040636},
   keywords = {methotrexate; cubic phase; magnetocubosomes; monoolein; liquid crystalline phase; drug delivery system; alternating magnetic field},
   language = {eng},
   issn = {2079-4991},
   journal = {Nanomaterials},
   title = {Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers},
   url = {https://www.mdpi.com/2079-4991/9/4/636},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 2409802
AU  - Mierzwa, Monika - Cytryniak, Adrianna - Krysinski, Pawel - Bilewicz, Renata
PY  - 2019
TI  - Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
JF  - Nanomaterials
VL  - 9
IS  - 4
SP  - 1-17
EP  - 1-17
PB  - MDPI
SN  - 20794991
KW  - methotrexate
KW  - cubic phase
KW  - magnetocubosomes
KW  - monoolein
KW  - liquid crystalline phase
KW  - drug delivery system
KW  - alternating magnetic field
UR  - https://www.mdpi.com/2079-4991/9/4/636
N2  - The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution.
ER  -

MIERZWA, Monika, Adrianna CYTRYNIAK, Pawel KRYSINSKI and Renata BILEWICZ. Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers. \textit{Nanomaterials}. BASEL: MDPI, 2019, vol.~9, No~4, p.~1-17. ISSN~2079-4991. Available from: https://dx.doi.org/10.3390/nano9040636.

Detailed Information on Publication Record