Thin TiO2 Coatings by ALD Enhance the Cell Growth on
TiO2 Nanotubular and Flat Substrates

J 2020

Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates

MOTOLA, Martin, Jan CAPEK, Raul ZAZPE, Jana BACOVA, Ludek HROMADKO et. al.

Basic information

Original name

Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates

Authors

Edition

ACS APPLIED BIO MATERIALS, WASHINGTON, AMER CHEMICAL SOC, 2020, 2576-6422

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

21000 2.10 Nano-technology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

DOI

http://dx.doi.org/10.1021/acsabm.0c00871

UT WoS

000604600600094

Keywords in English

TiO2 nanotube layers; Ti sheets; atomic layer deposition; coatings; cell growth

Abstract

V originále

The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials biocompatibility and is promising toward application in implant materials.

Links

90127, large research infrastructures

Name: CIISB II

Citovat

MOTOLA, Martin, Jan CAPEK, Raul ZAZPE, Jana BACOVA, Ludek HROMADKO, Lenka BRUCKOVA, Siowwoon NG, Jiri HANDL, Zdenek SPOTZ, Petr KNOTEK, Kaushik BAISHYA, Pavlina MAJTNEROVA, Jan PRIKRYL, Hanna SOPHA, Tomas ROUSAR and Jan M MACAK. Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates. ACS APPLIED BIO MATERIALS. WASHINGTON: AMER CHEMICAL SOC, 2020, vol. 3, No 9, p. 6447-6456. ISSN 2576-6422. Available from: https://dx.doi.org/10.1021/acsabm.0c00871.

@article{2409839,
 author = {Motola, Martin and Capek, Jan and Zazpe, Raul and Bacova, Jana and Hromadko, Ludek and Bruckova, Lenka and Ng, Siowwoon and Handl, Jiri and Spotz, Zdenek and Knotek, Petr and Baishya, Kaushik and Majtnerova, Pavlina and Prikryl, Jan and Sopha, Hanna and Rousar, Tomas and Macak, Jan M},
 article_location = {WASHINGTON},
 article_number = {9},
 doi = {http://dx.doi.org/10.1021/acsabm.0c00871},
 keywords = {TiO2 nanotube layers; Ti sheets; atomic layer deposition; coatings; cell growth},
 language = {eng},
 issn = {2576-6422},
 journal = {ACS APPLIED BIO MATERIALS},
 title = {Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates},
 url = {https://pubs.acs.org/doi/10.1021/acsabm.0c00871},
 volume = {3},
 year = {2020}
}

TY - JOUR
ID - 2409839
AU - Motola, Martin - Capek, Jan - Zazpe, Raul - Bacova, Jana - Hromadko, Ludek - Bruckova, Lenka - Ng, Siowwoon - Handl, Jiri - Spotz, Zdenek - Knotek, Petr - Baishya, Kaushik - Majtnerova, Pavlina - Prikryl, Jan - Sopha, Hanna - Rousar, Tomas - Macak, Jan M
PY - 2020
TI - Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates
JF - ACS APPLIED BIO MATERIALS
VL - 3
IS - 9
SP - 6447-6456
EP - 6447-6456
PB - AMER CHEMICAL SOC
SN - 25766422
KW - TiO2 nanotube layers
KW - Ti sheets
KW - atomic layer deposition
KW - coatings
KW - cell growth
UR - https://pubs.acs.org/doi/10.1021/acsabm.0c00871
N2 - The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials biocompatibility and is promising toward application in implant materials.
ER -

MOTOLA, Martin, Jan CAPEK, Raul ZAZPE, Jana BACOVA, Ludek HROMADKO, Lenka BRUCKOVA, Siowwoon NG, Jiri HANDL, Zdenek SPOTZ, Petr KNOTEK, Kaushik BAISHYA, Pavlina MAJTNEROVA, Jan PRIKRYL, Hanna SOPHA, Tomas ROUSAR and Jan M MACAK. Thin TiO\&{}lt;sub\&{}gt;2\&{}lt;/sub\&{}gt; Coatings by ALD Enhance the Cell Growth on TiO\&{}lt;sub\&{}gt;2\&{}lt;/sub\&{}gt; Nanotubular and Flat Substrates. \textit{ACS APPLIED BIO MATERIALS}. WASHINGTON: AMER CHEMICAL SOC, 2020, vol.~3, No~9, p.~6447-6456. ISSN~2576-6422. Available from: https://dx.doi.org/10.1021/acsabm.0c00871.

Detailed Information on Publication Record

Thin TiO<sub>2</sub> Coatings by ALD Enhance the Cell Growth on TiO<sub>2</sub> Nanotubular and Flat Substrates