Fullerene-Filtered Light Spectrum and Fullerenes Modulate
Emotional and Pain Processing in Mice

J 2021

Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC et. al.

Basic information

Original name

Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

Authors

LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC, Zorana JOVIC, Ivana STANKOVIC, Valentina MATOVIC and Djuro KORUGA

Edition

SYMMETRY-BASEL, SWITZERLAND, MDPI, 2021, 2073-8994

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.940

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3390/sym13112004

UT WoS

000806903700001

Keywords in English

fullerene; fullerenol; fullerenol water complex; emotional processing; anxiety; light spectrum; pain; resting state fMRI; MRI; behavior

Abstract

V originále

The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.

Links

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC, Zorana JOVIC, Ivana STANKOVIC, Valentina MATOVIC and Djuro KORUGA. Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. SYMMETRY-BASEL. SWITZERLAND: MDPI, 2021, vol. 13, No 11, p. 1-14. ISSN 2073-8994. Available from: https://dx.doi.org/10.3390/sym13112004.

@article{2409865,
   author = {Lazovic, Jelena and Zopf, Lydia M and Hren, Jernej and Gajdoš, Martin and Slavkovic, Marija and Jovic, Zorana and Stankovic, Ivana and Matovic, Valentina and Koruga, Djuro},
   article_location = {SWITZERLAND},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/sym13112004},
   keywords = {fullerene; fullerenol; fullerenol water complex; emotional processing; anxiety; light spectrum; pain; resting state fMRI; MRI; behavior},
   language = {eng},
   issn = {2073-8994},
   journal = {SYMMETRY-BASEL},
   title = {Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice},
   url = {https://www.mdpi.com/2073-8994/13/11/2004},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 2409865
AU  - Lazovic, Jelena - Zopf, Lydia M - Hren, Jernej - Gajdoš, Martin - Slavkovic, Marija - Jovic, Zorana - Stankovic, Ivana - Matovic, Valentina - Koruga, Djuro
PY  - 2021
TI  - Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
JF  - SYMMETRY-BASEL
VL  - 13
IS  - 11
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20738994
KW  - fullerene
KW  - fullerenol
KW  - fullerenol water complex
KW  - emotional processing
KW  - anxiety
KW  - light spectrum
KW  - pain
KW  - resting state fMRI
KW  - MRI
KW  - behavior
UR  - https://www.mdpi.com/2073-8994/13/11/2004
N2  - The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.
ER  -

LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC, Zorana JOVIC, Ivana STANKOVIC, Valentina MATOVIC and Djuro KORUGA. Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. \textit{SYMMETRY-BASEL}. SWITZERLAND: MDPI, 2021, vol.~13, No~11, p.~1-14. ISSN~2073-8994. Available from: https://dx.doi.org/10.3390/sym13112004.

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