Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study

JAKKA, Veera Venkata Satya Varaprasad and Jiri BURSA. Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study. Computers in Biology and Medicine. Oxford: Pergamon-Elsevier Science Press, 2022, vol. 143, Apr, p. 1-11. ISSN 0010-4825. Available from: https://dx.doi.org/10.1016/j.compbiomed.2022.105266.

Basic information

Original name

Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study

Authors

JAKKA, Veera Venkata Satya Varaprasad and Jiri BURSA

Edition

Computers in Biology and Medicine, Oxford, Pergamon-Elsevier Science Press, 2022, 0010-4825

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10201 Computer sciences, information science, bioinformatics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.700

DOI

http://dx.doi.org/10.1016/j.compbiomed.2022.105266

UT WoS

000788097600006

Keywords in English

Cell mechanics; Biaxial load; Finite element model; Bendo-tensegrity; Shear load

Tags

CF CELLIM, ne MU

Tags

International impact, Reviewed

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Abstract

V originále

Introduction: Computational modeling can enhance the understanding of cell mechanics. To achieve this, finite element models of endothelial cells were proposed with shapes mimicking their natural state inside the endothelium within the cardiovascular system. Implementing the recently proposed bendo-tensegrity concept, these models consider flexural (buckling) as well as tensional/compressional behavior of microtubules and also incorporate the waviness of intermediate filaments.Materials and methods: Four different models were created (flat and domed hexagons, both regular and elongated in the direction of blood flow) and loaded by biaxial deformation, blood pressure, and shear load from blood flow - natural physiological conditions of the arterial endothelium - aiming to investigate the "in situ" mechanical response of the cell.Results: The impact of individual components of loads on the nucleus deformation (more specifically on the first principal strain) potentially influencing mechanotransduction was investigated and the role of the cytoskeleton and its constituents in the mechanical response of the endothelial cell was assessed. The results show (i) the impact of pulsating blood pressure on cyclic deformations of the nucleus, which increase substantially with decreasing axial pre-stretch of the cell, (ii) the importance of relatively low shear stresses in the cell response and nucleus deformation.Conclusion: Not only the pulsatile blood pressure but also the wall shear stress may induce significant deformation of the nucleus and thus trigger remodelation processes in endothelial cells.