Detailed Information on Publication Record
2024
What is the impact of plastic deformation on cytocompatibility of biodegradable Zn–Mg alloys?
WOJTAS, Daniel, Klaudia TREMBECKA-WÓJCIGA, Magdalena GIELECIAK, Agnieszka BIGOS, Kamil BRUDECKI et. al.Basic information
Original name
What is the impact of plastic deformation on cytocompatibility of biodegradable Zn–Mg alloys?
Authors
WOJTAS, Daniel (616 Poland, belonging to the institution), Klaudia TREMBECKA-WÓJCIGA, Magdalena GIELECIAK, Agnieszka BIGOS, Kamil BRUDECKI, Sylwia PRZYBYSZ-GLOC, Romana SCHIRHAGL, Aldona MZYK and Anna JARZĘBSKA
Edition
MATERIALS ADVANCES, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2024, 2633-5409
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
20601 Medical engineering
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.000 in 2022
Organization unit
Faculty of Medicine
UT WoS
001250669600001
Keywords in English
biodegradable Zn-Mg alloys; plastic deformation; cytocompatibility
Tags
International impact, Reviewed
Změněno: 5/11/2024 14:08, Mgr. Tereza Miškechová
Abstract
V originále
Research on biodegradable zinc requires thorough in vitro cytotoxicity screening as the developed materials are being proposed for various medical implants, including stents. This study investigates the endothelial cell response to a novel Zn–0.8Mg alloy produced via hydrostatic extrusion (HSE), aiming to showcase the impact of plastic deformation on the cytocompatibility of biodegradable zinc-based materials. In doing so, the MTT test for cell viability studies as well as confocal laser scanning microscopy (CLSM) imaging for cell morphology analysis were used. In addition, a cutting-edge diamond-based quantum sensing technique, i.e., T1 relaxometry, was employed to reveal the nanoscale impact of ions on cells. It was demonstrated that the HSE-produced materials exhibited a 10-fold decrease in grain size, microstructural homogenization, and consequently more uniform degradation compared to hot extruded, coarse-grained materials. Despite these differences, the MTT and CLSM data did not show any drastic discrepancies between the endothelial cell response to any of the investigated materials. However, T1 relaxometry measurements indicated that plastic deformation might influence the cytocompatibility of biodegradable zinc-based materials, as evidenced by significant intracellular free radical production in endothelial cells exposed to ions released from the Zn–0.8Mg HSE alloy surface. Overall, no adverse effects of plastic deformation on the cytocompatibility of zinc-based materials were found as free radical generation may play a beneficial role in endothelial cell function, suggesting a complex interaction between material degradation and cellular response.