RNAs in tumour-derived extracellular vesicles and their
significance in the tumour microenvironment

J 2024

RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA et. al.

Basic information

Original name

RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

Authors

BUGAJOVÁ, Mária (703 Slovakia, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), David KALFERT (203 Czech Republic), Jan BETKA (203 Czech Republic) and Jan BALVAN (203 Czech Republic, belonging to the institution)

Edition

International journal of cancer, HOBOKEN, International Union Against Cancer, 2024, 0020-7136

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.400 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/ijc.35035

UT WoS

001240512100001

Keywords in English

metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment

Abstract

V originále

Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.

Links

GA21-06873S, research and development project

Name: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku

Investor: Czech Science Foundation

MUNI/A/1343/2022, interní kód MU

Name: Zátěže kardiovaskulárního systému od A po Z

Investor: Masaryk University, Loads on the cardiovascular system from A to Z

MUNI/A/1370/2022, interní kód MU

Name: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masaryk University, Pathophysiology of selected complex diseases from molecular to systemic level

NU20J-08-00018, research and development project

Name: Exosomální RNA produkovaná fibroblasty asociovanými s nádorem jako relevantní marker v prognóze nádorů hlavy a krku

Investor: Ministry of Health of the CR, Subprogram 2 - junior

Citovat

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA and Jan BALVAN. RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment. International journal of cancer. HOBOKEN: International Union Against Cancer, 2024, vol. 155, No 7, p. 1147-1161. ISSN 0020-7136. Available from: https://dx.doi.org/10.1002/ijc.35035.

@article{2416017,
   author = {Bugajová, Mária and Raudenská, Martina and Masařík, Michal and Kalfert, David and Betka, Jan and Balvan, Jan},
   article_location = {HOBOKEN},
   article_number = {7},
   doi = {http://dx.doi.org/10.1002/ijc.35035},
   keywords = {metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment},
   language = {eng},
   issn = {0020-7136},
   journal = {International journal of cancer},
   title = {RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035},
   volume = {155},
   year = {2024}
}

TY  - JOUR
ID  - 2416017
AU  - Bugajová, Mária - Raudenská, Martina - Masařík, Michal - Kalfert, David - Betka, Jan - Balvan, Jan
PY  - 2024
TI  - RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment
JF  - International journal of cancer
VL  - 155
IS  - 7
SP  - 1147-1161
EP  - 1147-1161
PB  - International Union Against Cancer
SN  - 00207136
KW  - metastasis
KW  - resistance to therapy
KW  - RNA
KW  - small extracellular vesicles
KW  - tumour microenvironment
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035
N2  - Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.
ER  -

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA and Jan BALVAN. RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2024, vol.~155, No~7, p.~1147-1161. ISSN~0020-7136. Available from: https://dx.doi.org/10.1002/ijc.35035.

Detailed Information on Publication Record