Detailed Information on Publication Record
2024
Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Yuliya S NIKOLOVA et. al.Basic information
Original name
Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
Authors
MAREČKOVÁ, Klára (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Yuliya S NIKOLOVA
Edition
Translational Psychiatry, London, Springer Nature, 2024, 2158-3188
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30215 Psychiatry
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 6.800 in 2022
Organization unit
Faculty of Medicine
UT WoS
001234528500002
Keywords in English
alcohol; prenatal exposure; reward processing; substance use
Tags
International impact, Reviewed
Změněno: 6/8/2024 11:10, Mgr. Tereza Miškechová
Abstract
V originále
Heavy maternal alcohol drinking during pregnancy has been associated with altered neurodevelopment in the child but the effects of low-dose alcohol drinking are less clear and any potential safe level of alcohol use during pregnancy is not known. We evaluated the effects of prenatal alcohol on reward-related behavior and substance use in young adulthood and the potential sex differences therein. Participants were members of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) prenatal birth cohort who participated in its neuroimaging follow-up in young adulthood. A total of 191 participants (28-30 years; 51% men) had complete data on prenatal exposure to alcohol, current substance use, and fMRI data from young adulthood. Maternal alcohol drinking was assessed during mid-pregnancy and pre-conception. Brain response to reward anticipation and reward feedback was measured using the Monetary Incentive Delay task and substance use in young adulthood was assessed using a self-report questionnaire. We showed that even a moderate exposure to alcohol in mid-pregnancy but not pre-conception was associated with robust effects on brain response to reward feedback (six frontal, one parietal, one temporal, and one occipital cluster) and with greater cannabis use in both men and women 30 years later. Moreover, mid-pregnancy but not pre-conception exposure to alcohol was associated with greater cannabis use in young adulthood and these effects were independent of maternal education and maternal depression during pregnancy. Further, the extent of cannabis use in the late 20 s was predicted by the brain response to reward feedback in three out of the nine prenatal alcohol-related clusters and these effects were independent of current alcohol use. Sex differences in the brain response to reward outcome emerged only during the no loss vs. loss contrast. Young adult men exposed to alcohol prenatally had significantly larger brain response to no loss vs. loss in the putamen and occipital region than women exposed to prenatal alcohol. Therefore, we conclude that even moderate exposure to alcohol prenatally has long-lasting effects on brain function during reward processing and risk of cannabis use in young adulthood.
Links
| EF17_043/0009632, research and development project |
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| GM24-12183M, research and development project |
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| LM2018121, research and development project |
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| LM2018129, research and development project |
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| LQ1601, research and development project |
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| NU20J-04-00022, research and development project |
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