Human Endogenous Retroviruses in Breast Cancer: Altered
Expression Pattern Implicates Divergent Roles in Carcinogenesis

J 2024

Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA et. al.

Basic information

Original name

Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis

Authors

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA and Ondrej SLANAR

Edition

Oncology, Basel, Karger, 2024, 0030-2414

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.500 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000538021

UT WoS

001243070800001

Keywords in English

Breast cancer; Human endogenous retroviruses; ERVW-1; ERVFRD-1; ERVV-1; ERV3-1; ERVH48-1; ERVMER34-1; ERVK13-1; ERVK3-1; HCP5

Abstract

V originále

Introduction: Breast cancer is the most common cancer and the leading cause of cancer death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but the data remain controversial. Methods: HERVs' expression was evaluated to show the differences between breast cancer and control samples, and their associations with clinicopathological parameters. Gene expression of 12 HERVs, i.e., ERVE-4, ERVW-1, ERVFRD-1, ERVV-1, ERV3-1, ERVH48-1, ERVMER34-1, ERVK-7, ERVK13-1, ERVK11-1, ERVK3-1, and HCP5, was analyzed by qPCR and/or TCGA datasets for breast cancer. Results: ERV3-1, ERVFRD-1, ERVH48-1, and ERVW-1 provided data to support their tumor suppressor roles in breast cancer. ERV3-1 evinced the best performing diagnostic data based on qPCR, i.e., AUC: 0.819 (p < 0.0001), sensitivity of 72.41%, and specificity of 89.66%. Lower levels of ERV3-1 were noted in advanced stage and higher grades, and significant negative association was found in relation to Ki-67 levels. Oncogenic roles may be inferred for ERVK13-1, ERVV-1, and ERVMER34-1. Data for ERVK-7, ERVE-4, ERVK11-1, and HCP5 remain inconclusive. Conclusion: Differential HERV expression may be applicable to evaluate novel biomarkers for breast cancer. However, more research is needed to reveal their real clinical impact, the biological roles, and regulatory mechanisms in breast carcinogenesis. (c) 2024 The Author(s).Published by S. Karger AG, Basel

Citovat

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA and Ondrej SLANAR. Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis. Oncology. Basel: Karger, 2024, 10 pp. ISSN 0030-2414. Available from: https://dx.doi.org/10.1159/000538021.

@article{2416262,
   author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Kohoutova, Milada and Slanar, Ondrej},
   article_location = {Basel},
   doi = {http://dx.doi.org/10.1159/000538021},
   keywords = {Breast cancer; Human endogenous retroviruses; ERVW-1; ERVFRD-1; ERVV-1; ERV3-1; ERVH48-1; ERVMER34-1; ERVK13-1; ERVK3-1; HCP5},
   language = {eng},
   issn = {0030-2414},
   journal = {Oncology},
   title = {Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis},
   url = {https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer},
   year = {2024}
}

TY  - JOUR
ID  - 2416262
AU  - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Kohoutova, Milada - Slanar, Ondrej
PY  - 2024
TI  - Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis
JF  - Oncology
PB  - Karger
SN  - 00302414
KW  - Breast cancer
KW  - Human endogenous retroviruses
KW  - ERVW-1
KW  - ERVFRD-1
KW  - ERVV-1
KW  - ERV3-1
KW  - ERVH48-1
KW  - ERVMER34-1
KW  - ERVK13-1
KW  - ERVK3-1
KW  - HCP5
UR  - https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer
N2  - Introduction: Breast cancer is the most common cancer and the leading cause of cancer death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but the data remain controversial. Methods: HERVs' expression was evaluated to show the differences between breast cancer and control samples, and their associations with clinicopathological parameters. Gene expression of 12 HERVs, i.e., ERVE-4, ERVW-1, ERVFRD-1, ERVV-1, ERV3-1, ERVH48-1, ERVMER34-1, ERVK-7, ERVK13-1, ERVK11-1, ERVK3-1, and HCP5, was analyzed by qPCR and/or TCGA datasets for breast cancer. Results: ERV3-1, ERVFRD-1, ERVH48-1, and ERVW-1 provided data to support their tumor suppressor roles in breast cancer. ERV3-1 evinced the best performing diagnostic data based on qPCR, i.e., AUC: 0.819 (p < 0.0001), sensitivity of 72.41%, and specificity of 89.66%. Lower levels of ERV3-1 were noted in advanced stage and higher grades, and significant negative association was found in relation to Ki-67 levels. Oncogenic roles may be inferred for ERVK13-1, ERVV-1, and ERVMER34-1. Data for ERVK-7, ERVE-4, ERVK11-1, and HCP5 remain inconclusive. Conclusion: Differential HERV expression may be applicable to evaluate novel biomarkers for breast cancer. However, more research is needed to reveal their real clinical impact, the biological roles, and regulatory mechanisms in breast carcinogenesis. (c) 2024 The Author(s).Published by S. Karger AG, Basel
ER  -

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA and Ondrej SLANAR. Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis. \textit{Oncology}. Basel: Karger, 2024, 10 pp. ISSN~0030-2414. Available from: https://dx.doi.org/10.1159/000538021.

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