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@article{2416262,
author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Kohoutova, Milada and Slanar, Ondrej},
article_location = {Basel},
doi = {http://dx.doi.org/10.1159/000538021},
keywords = {Breast cancer; Human endogenous retroviruses; ERVW-1; ERVFRD-1; ERVV-1; ERV3-1; ERVH48-1; ERVMER34-1; ERVK13-1; ERVK3-1; HCP5},
language = {eng},
issn = {0030-2414},
journal = {Oncology},
title = {Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis},
url = {https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer},
year = {2024}
}
TY - JOUR
ID - 2416262
AU - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Kohoutova, Milada - Slanar, Ondrej
PY - 2024
TI - Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis
JF - Oncology
PB - Karger
SN - 00302414
KW - Breast cancer
KW - Human endogenous retroviruses
KW - ERVW-1
KW - ERVFRD-1
KW - ERVV-1
KW - ERV3-1
KW - ERVH48-1
KW - ERVMER34-1
KW - ERVK13-1
KW - ERVK3-1
KW - HCP5
UR - https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer
N2 - Introduction: Breast cancer is the most common cancer and the leading cause of cancer death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but the data remain controversial. Methods: HERVs' expression was evaluated to show the differences between breast cancer and control samples, and their associations with clinicopathological parameters. Gene expression of 12 HERVs, i.e., ERVE-4, ERVW-1, ERVFRD-1, ERVV-1, ERV3-1, ERVH48-1, ERVMER34-1, ERVK-7, ERVK13-1, ERVK11-1, ERVK3-1, and HCP5, was analyzed by qPCR and/or TCGA datasets for breast cancer. Results: ERV3-1, ERVFRD-1, ERVH48-1, and ERVW-1 provided data to support their tumor suppressor roles in breast cancer. ERV3-1 evinced the best performing diagnostic data based on qPCR, i.e., AUC: 0.819 (p < 0.0001), sensitivity of 72.41%, and specificity of 89.66%. Lower levels of ERV3-1 were noted in advanced stage and higher grades, and significant negative association was found in relation to Ki-67 levels. Oncogenic roles may be inferred for ERVK13-1, ERVV-1, and ERVMER34-1. Data for ERVK-7, ERVE-4, ERVK11-1, and HCP5 remain inconclusive. Conclusion: Differential HERV expression may be applicable to evaluate novel biomarkers for breast cancer. However, more research is needed to reveal their real clinical impact, the biological roles, and regulatory mechanisms in breast carcinogenesis. (c) 2024 The Author(s).Published by S. Karger AG, Basel
ER -
ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA and Ondrej SLANAR. Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis. \textit{Oncology}. Basel: Karger, 2024, 10 pp. ISSN~0030-2414. Available from: https://dx.doi.org/10.1159/000538021.
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