| SKERENOVA, Maria, Michal CIBULKA, Zuzana DANKOVA, Veronika HOLUBEKOVA, Zuzana KOLKOVA, Vincent LUCANSKY, Dana DVORSKA, Andrea KAPINOVA, Michaela KRIVOSOVA, Martin PETRAS, Eva BARANOVICOVA, Ivana BARANOVA, Elena NOVAKOVA, Peter LIPTAK, Peter BANOVCIN, Anna BOBCAKOVA, Robert ROSOLANKA, Maria JANICKOVA, Andrea STANCLOVA, Ludovit GASPAR, Martin CAPRNDA, Robert PROSECKÝ, Monika LABUDOVA, Zufar GABBASOV, Luis RODRIGO, Peter KRUŽLIAK, Zora LASABOVA, Tatiana MATAKOVA and Erika HALASOVA. Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort. Advances in Medical Sciences. WROCLAW: ELSEVIER URBAN & PARTNER SP Z O O, 2024, vol. 69, No 1, p. 198-207. ISSN 1896-1126. Available from: https://dx.doi.org/10.1016/j.advms.2024.03.007. |
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@article{2417618,
author = {Skerenova, Maria and Cibulka, Michal and Dankova, Zuzana and Holubekova, Veronika and Kolkova, Zuzana and Lucansky, Vincent and Dvorska, Dana and Kapinova, Andrea and Krivosova, Michaela and Petras, Martin and Baranovicova, Eva and Baranova, Ivana and Novakova, Elena and Liptak, Peter and Banovcin, Peter and Bobcakova, Anna and Rosolanka, Robert and Janickova, Maria and Stanclova, Andrea and Gaspar, Ludovit and Caprnda, Martin and Prosecký, Robert and Labudova, Monika and Gabbasov, Zufar and Rodrigo, Luis and Kružliak, Peter and Lasabova, Zora and Matakova, Tatiana and Halasova, Erika},
article_location = {WROCLAW},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.advms.2024.03.007},
keywords = {Haplotypes; Host genetic risk factors; Immunoregulatory pathways; Severe acute respiratory syndrome coronavirus 2; Single nucleotide variants},
language = {eng},
issn = {1896-1126},
journal = {Advances in Medical Sciences},
title = {Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort},
url = {https://www.sciencedirect.com/science/article/pii/S1896112624000208?via%3Dihub},
volume = {69},
year = {2024}
}
TY - JOUR
ID - 2417618
AU - Skerenova, Maria - Cibulka, Michal - Dankova, Zuzana - Holubekova, Veronika - Kolkova, Zuzana - Lucansky, Vincent - Dvorska, Dana - Kapinova, Andrea - Krivosova, Michaela - Petras, Martin - Baranovicova, Eva - Baranova, Ivana - Novakova, Elena - Liptak, Peter - Banovcin, Peter - Bobcakova, Anna - Rosolanka, Robert - Janickova, Maria - Stanclova, Andrea - Gaspar, Ludovit - Caprnda, Martin - Prosecký, Robert - Labudova, Monika - Gabbasov, Zufar - Rodrigo, Luis - Kružliak, Peter - Lasabova, Zora - Matakova, Tatiana - Halasova, Erika
PY - 2024
TI - Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort
JF - Advances in Medical Sciences
VL - 69
IS - 1
SP - 198-207
EP - 198-207
PB - ELSEVIER URBAN & PARTNER SP Z O O
SN - 18961126
KW - Haplotypes
KW - Host genetic risk factors
KW - Immunoregulatory pathways
KW - Severe acute respiratory syndrome coronavirus 2
KW - Single nucleotide variants
UR - https://www.sciencedirect.com/science/article/pii/S1896112624000208?via%3Dihub
N2 - We present the results of an association study involving hospitalized coronavirus disease 2019 (COVID-19) patients with a clinical background during the 3rd pandemic wave of COVID-19 in Slovakia. Seventeen single nucleotide variants (SNVs) in the eleven most relevant genes, according to the COVID-19 Host Genetics Initiative, were investigated. Our study confirms the validity of the influence of LZTFL1 and 2 '-5 '-oligoadenylate synthetase (OAS)1/OAS3 genetic variants on the severity of COVID-19. For two LZTFL1 SNVs in complete linkage disequilibrium, rs17713054 and rs73064425, the odds ratios of baseline allelic associations and logistic regressions (LR) adjusted for age and sex ranged in the four tested designs from 2.04 to 2.41 and from 2.05 to 3.98, respectively. The OAS1/OAS3 haplotype 'gttg' carrying a functional allele G of splice-acceptor variant rs10774671 manifested its protective function in the Delta pandemic wave. Significant baseline allelic associations of two DPP9 variants in all tested designs and two IFNAR2 variants in the Omicron pandemic wave were not confirmed by adjusted LR. Nevertheless, adjusted LR showed significant associations of NOTCH4 rs3131294 and TYK2 rs2304256 variants with severity of COVID-19. Hospitalized patients' reported comorbidities were not correlated with genetic variants, except for obesity, smoking (IFNAR2), and hypertension (NOTCH4). The results of our study suggest that host genetic variations have an impact on the severity and duration of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Considering the differences in allelic associations between pandemic waves, they support the hypothesis that every new SARS-CoV-2 variant may modify the host immune response by reconfiguring involved pathways.
ER -
SKERENOVA, Maria, Michal CIBULKA, Zuzana DANKOVA, Veronika HOLUBEKOVA, Zuzana KOLKOVA, Vincent LUCANSKY, Dana DVORSKA, Andrea KAPINOVA, Michaela KRIVOSOVA, Martin PETRAS, Eva BARANOVICOVA, Ivana BARANOVA, Elena NOVAKOVA, Peter LIPTAK, Peter BANOVCIN, Anna BOBCAKOVA, Robert ROSOLANKA, Maria JANICKOVA, Andrea STANCLOVA, Ludovit GASPAR, Martin CAPRNDA, Robert PROSECKÝ, Monika LABUDOVA, Zufar GABBASOV, Luis RODRIGO, Peter KRUŽLIAK, Zora LASABOVA, Tatiana MATAKOVA and Erika HALASOVA. Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort. \textit{Advances in Medical Sciences}. WROCLAW: ELSEVIER URBAN \&{} PARTNER SP Z O O, 2024, vol.~69, No~1, p.~198-207. ISSN~1896-1126. Available from: https://dx.doi.org/10.1016/j.advms.2024.03.007.
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