Orofacial clefts are one of the most common congenital malformations worldwide. The incidence of the newborns with orofacial clefts is approximately 1.7 in 1000 live births and varies across regions, ethnicities, risk factors, and other variables. In the Czech Republic, the incidence is one cleft child in 600 healthy newborns. Patients with cleft have higher mortality and morbidity than those without cleft . Orofacial clefts have been extensively reviewed in previous literature; the most common are nonsyndromic clefts including cleft lip and palate (CLP), cleft lip (CL), and cleft palate (CP) alone. According to a large European study, 71 % of cleft lip with or without cleft palate (CL/P) cases were isolated, whereas 29 % were linked to other anomalies. Associated malformations are more often reported in patients with CLP (34.0 %) than patients with CL (20.8 %).