Ultra-high-frequency ECG volumetric and negative derivative
epicardial ventricular electrical activation pattern

J 2024

Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern

LEINVEBER, Pavel, Josef HALAMEK, Karol CURILA, Frits PRINZEN, Jolana LIPOLDOVÁ et. al.

Basic information

Original name

Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern

Authors

LEINVEBER, Pavel (203 Czech Republic), Josef HALAMEK (203 Czech Republic), Karol CURILA (203 Czech Republic), Frits PRINZEN, Jolana LIPOLDOVÁ (203 Czech Republic, belonging to the institution), Magdalena MATEJKOVA (203 Czech Republic), Radovan SMISEK (203 Czech Republic), Filip PLESINGER (203 Czech Republic), Andrej NAGY (703 Slovakia, belonging to the institution), Miroslav NOVÁK (203 Czech Republic, belonging to the institution), Ivo VISCOR (203 Czech Republic), Vlastimil VONDRA (203 Czech Republic) and Pavel JURAK (203 Czech Republic)

Edition

Nature Scientific Reports, Berlin, NATURE RESEARCH, 2024, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-024-55789-w

UT WoS

001185083700069

Keywords in English

ECG

Abstract

V originále

From precordial ECG leads, the conventional determination of the negative derivative of the QRS complex (ND-ECG) assesses epicardial activation. Recently we showed that ultra-high-frequency electrocardiography (UHF-ECG) determines the activation of a larger volume of the ventricular wall. We aimed to combine these two methods to investigate the potential of volumetric and epicardial ventricular activation assessment and thereby determine the transmural activation sequence. We retrospectively analyzed 390 ECG records divided into three groups-healthy subjects with normal ECG, left bundle branch block (LBBB), and right bundle branch block (RBBB) patients. Then we created UHF-ECG and ND-ECG-derived depolarization maps and computed interventricular electrical dyssynchrony. Characteristic spatio-temporal differences were found between the volumetric UHF-ECG activation patterns and epicardial ND-ECG in the Normal, LBBB, and RBBB groups, despite the overall high correlations between both methods. Interventricular electrical dyssynchrony values assessed by the ND-ECG were consistently larger than values computed by the UHF-ECG method. Noninvasively obtained UHF-ECG and ND-ECG analyses describe different ventricular dyssynchrony and the general course of ventricular depolarization. Combining both methods based on standard 12-lead ECG electrode positions allows for a more detailed analysis of volumetric and epicardial ventricular electrical activation, including the assessment of the depolarization wave direction propagation in ventricles.

Citovat

LEINVEBER, Pavel, Josef HALAMEK, Karol CURILA, Frits PRINZEN, Jolana LIPOLDOVÁ, Magdalena MATEJKOVA, Radovan SMISEK, Filip PLESINGER, Andrej NAGY, Miroslav NOVÁK, Ivo VISCOR, Vlastimil VONDRA and Pavel JURAK. Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern. Nature Scientific Reports. Berlin: NATURE RESEARCH, 2024, vol. 14, No 1, p. 1-11. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-024-55789-w.

@article{2417670,
   author = {Leinveber, Pavel and Halamek, Josef and Curila, Karol and Prinzen, Frits and Lipoldová, Jolana and Matejkova, Magdalena and Smisek, Radovan and Plesinger, Filip and Nagy, Andrej and Novák, Miroslav and Viscor, Ivo and Vondra, Vlastimil and Jurak, Pavel},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-024-55789-w},
   keywords = {ECG},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern},
   url = {https://www.nature.com/articles/s41598-024-55789-w},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2417670
AU  - Leinveber, Pavel - Halamek, Josef - Curila, Karol - Prinzen, Frits - Lipoldová, Jolana - Matejkova, Magdalena - Smisek, Radovan - Plesinger, Filip - Nagy, Andrej - Novák, Miroslav - Viscor, Ivo - Vondra, Vlastimil - Jurak, Pavel
PY  - 2024
TI  - Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern
JF  - Nature Scientific Reports
VL  - 14
IS  - 1
SP  - 1-11
EP  - 1-11
PB  - NATURE RESEARCH
SN  - 20452322
KW  - ECG
UR  - https://www.nature.com/articles/s41598-024-55789-w
N2  - From precordial ECG leads, the conventional determination of the negative derivative of the QRS complex (ND-ECG) assesses epicardial activation. Recently we showed that ultra-high-frequency electrocardiography (UHF-ECG) determines the activation of a larger volume of the ventricular wall. We aimed to combine these two methods to investigate the potential of volumetric and epicardial ventricular activation assessment and thereby determine the transmural activation sequence. We retrospectively analyzed 390 ECG records divided into three groups-healthy subjects with normal ECG, left bundle branch block (LBBB), and right bundle branch block (RBBB) patients. Then we created UHF-ECG and ND-ECG-derived depolarization maps and computed interventricular electrical dyssynchrony. Characteristic spatio-temporal differences were found between the volumetric UHF-ECG activation patterns and epicardial ND-ECG in the Normal, LBBB, and RBBB groups, despite the overall high correlations between both methods. Interventricular electrical dyssynchrony values assessed by the ND-ECG were consistently larger than values computed by the UHF-ECG method. Noninvasively obtained UHF-ECG and ND-ECG analyses describe different ventricular dyssynchrony and the general course of ventricular depolarization. Combining both methods based on standard 12-lead ECG electrode positions allows for a more detailed analysis of volumetric and epicardial ventricular electrical activation, including the assessment of the depolarization wave direction propagation in ventricles.
ER  -

LEINVEBER, Pavel, Josef HALAMEK, Karol CURILA, Frits PRINZEN, Jolana LIPOLDOVÁ, Magdalena MATEJKOVA, Radovan SMISEK, Filip PLESINGER, Andrej NAGY, Miroslav NOVÁK, Ivo VISCOR, Vlastimil VONDRA and Pavel JURAK. Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern. \textit{Nature Scientific Reports}. Berlin: NATURE RESEARCH, 2024, vol.~14, No~1, p.~1-11. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-024-55789-w.

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