Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
Authors
GIUSEPPE, De Luca, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura I FERRER, Alexandre QUADROS, Marek MILEWSKI, Fortunato Scotto UCCIO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA (203 Czech Republic, belonging to the institution), Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-Yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Lux ARPAD, Marinucci LUCIA, Guiducci VINCENZO, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Flavien VINCENT, Enrico FABRIS, Lozano Martinez-Luengas INIGO, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Brum Silveira Joao ANTONIO, Rodrigo ZONI, Ivan BESSONOV, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKIS, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Giuliana CORTESE, Guido PARODI, Mohamed Abed BOURAGHDA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA, Matteo NARDIN and Monica VERDOIA
Edition
Journal of Clinical Medicine, Basel, MDPI, 2022, 2077-0383
The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.
GIUSEPPE, De Luca, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura I FERRER, Alexandre QUADROS, Marek MILEWSKI, Fortunato Scotto UCCIO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA, Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-Yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Lux ARPAD, Marinucci LUCIA, Guiducci VINCENZO, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Flavien VINCENT, Enrico FABRIS, Lozano Martinez-Luengas INIGO, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Brum Silveira Joao ANTONIO, Rodrigo ZONI, Ivan BESSONOV, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKIS, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Giuliana CORTESE, Guido PARODI, Mohamed Abed BOURAGHDA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA, Matteo NARDIN and Monica VERDOIA. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry. Journal of Clinical Medicine. Basel: MDPI, 2022, vol. 11, No 22, p. 1-13. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm11226722.
@article{2417949, author = {Giuseppe, De Luca and Algowhary, Magdy and Uguz, Berat and Oliveira, Dinaldo C and Ganyukov, Vladimir and Zimbakov, Zan and Cercek, Miha and Jensen, Lisette Okkels and Loh, Poay Huan and Calmac, Lucian and Ferrer, Gerard Roura I and Quadros, Alexandre and Milewski, Marek and Uccio, Fortunato Scotto and Clemens, von Birgelen and Versaci, Francesco and Jurrien, Ten Berg and Casella, Gianni and Lung, Aaron Wong Sung and Kala, Petr and Gil, Jose Luis Diez and Carrillo, Xavier and Dirksen, Maurits and BecerraandMunoz, Victor M and Lee, Michael KangandYin and Juzar, Dafsah Arifa and Joaquim, Rodrigo de Moura and Paladino, Roberto and Milicic, Davor and Davlouros, Periklis and Bakraceski, Nikola and Zilio, Filippo and Donazzan, Luca and Kraaijeveld, Adriaan and Galasso, Gennaro and Arpad, Lux and Lucia, Marinucci and Vincenzo, Guiducci and Menichelli, Maurizio and Scoccia, Alessandra and Yamac, Aylin Hatice and Mert, Kadir Ugur and Rios, Xacobe Flores and Kovarnik, Tomas and Kidawa, Michal and Moreu, Jose and Vincent, Flavien and Fabris, Enrico and Inigo, Lozano MartinezandLuengas and Boccalatte, Marco and Ojeda, Francisco Bosa and ArellanoandSerrano, Carlos and Caiazzo, Gianluca and Cirrincione, Giuseppe and Kao, HsienandLi and Fores, Juan Sanchis and Vignali, Luigi and Pereira, Helder and Manzo, Stephane and Ordonez, Santiago and Ozkan, Alev Arat and Scheller, Bruno and Lehtola, Heidi and Teles, Rui and Mantis, Christos and Antti, Ylitalo and Antonio, Brum Silveira Joao and Zoni, Rodrigo and Bessonov, Ivan and Savonitto, Stefano and Kochiadakis, George and Alexopulos, Dimitrios and Uribe, Carlos E and Kanakakis, John and Faurie, Benjamin and Gabrielli, Gabriele and Barrios, Alejandro Gutierrez and Bachini, Juan Pablo and Rocha, Alex and Tam, Frankie ChorandCheung and Rodriguez, Alfredo and Lukito, Antonia Anna and SaintandJoy, Veauthyelau and Pessah, Gustavo and Tuccillo, Andrea and Cortese, Giuliana and Parodi, Guido and Bouraghda, Mohamed Abed and Kedhi, Elvin and Lamelas, Pablo and Suryapranata, Harry and Nardin, Matteo and Verdoia, Monica}, article_location = {Basel}, article_number = {22}, doi = {http://dx.doi.org/10.3390/jcm11226722}, keywords = {myocardial infarction; smoking paradox; percutaneous coronary intervention; COVID-19}, language = {eng}, issn = {2077-0383}, journal = {Journal of Clinical Medicine}, title = {Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry}, url = {https://www.mdpi.com/2077-0383/11/22/6722}, volume = {11}, year = {2022} }
TY - JOUR ID - 2417949 AU - Giuseppe, De Luca - Algowhary, Magdy - Uguz, Berat - Oliveira, Dinaldo C - Ganyukov, Vladimir - Zimbakov, Zan - Cercek, Miha - Jensen, Lisette Okkels - Loh, Poay Huan - Calmac, Lucian - Ferrer, Gerard Roura I - Quadros, Alexandre - Milewski, Marek - Uccio, Fortunato Scotto - Clemens, von Birgelen - Versaci, Francesco - Jurrien, Ten Berg - Casella, Gianni - Lung, Aaron Wong Sung - Kala, Petr - Gil, Jose Luis Diez - Carrillo, Xavier - Dirksen, Maurits - Becerra-Munoz, Victor M - Lee, Michael Kang-Yin - Juzar, Dafsah Arifa - Joaquim, Rodrigo de Moura - Paladino, Roberto - Milicic, Davor - Davlouros, Periklis - Bakraceski, Nikola - Zilio, Filippo - Donazzan, Luca - Kraaijeveld, Adriaan - Galasso, Gennaro - Arpad, Lux - Lucia, Marinucci - Vincenzo, Guiducci - Menichelli, Maurizio - Scoccia, Alessandra - Yamac, Aylin Hatice - Mert, Kadir Ugur - Rios, Xacobe Flores - Kovarnik, Tomas - Kidawa, Michal - Moreu, Jose - Vincent, Flavien - Fabris, Enrico - Inigo, Lozano Martinez-Luengas - Boccalatte, Marco - Ojeda, Francisco Bosa - Arellano-Serrano, Carlos - Caiazzo, Gianluca - Cirrincione, Giuseppe - Kao, Hsien-Li - Fores, Juan Sanchis - Vignali, Luigi - Pereira, Helder - Manzo, Stephane - Ordonez, Santiago - Ozkan, Alev Arat - Scheller, Bruno - Lehtola, Heidi - Teles, Rui - Mantis, Christos - Antti, Ylitalo - Antonio, Brum Silveira Joao - Zoni, Rodrigo - Bessonov, Ivan - Savonitto, Stefano - Kochiadakis, George - Alexopulos, Dimitrios - Uribe, Carlos E - Kanakakis, John - Faurie, Benjamin - Gabrielli, Gabriele - Barrios, Alejandro Gutierrez - Bachini, Juan Pablo - Rocha, Alex - Tam, Frankie Chor-Cheung - Rodriguez, Alfredo - Lukito, Antonia Anna - Saint-Joy, Veauthyelau - Pessah, Gustavo - Tuccillo, Andrea - Cortese, Giuliana - Parodi, Guido - Bouraghda, Mohamed Abed - Kedhi, Elvin - Lamelas, Pablo - Suryapranata, Harry - Nardin, Matteo - Verdoia, Monica PY - 2022 TI - Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry JF - Journal of Clinical Medicine VL - 11 IS - 22 SP - 1-13 EP - 1-13 PB - MDPI SN - 20770383 KW - myocardial infarction KW - smoking paradox KW - percutaneous coronary intervention KW - COVID-19 UR - https://www.mdpi.com/2077-0383/11/22/6722 N2 - The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history. ER -
GIUSEPPE, De Luca, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura I FERRER, Alexandre QUADROS, Marek MILEWSKI, Fortunato Scotto UCCIO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA, Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-Yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Lux ARPAD, Marinucci LUCIA, Guiducci VINCENZO, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Flavien VINCENT, Enrico FABRIS, Lozano Martinez-Luengas INIGO, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Brum Silveira Joao ANTONIO, Rodrigo ZONI, Ivan BESSONOV, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKIS, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Giuliana CORTESE, Guido PARODI, Mohamed Abed BOURAGHDA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA, Matteo NARDIN and Monica VERDOIA. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2022, vol.~11, No~22, p.~1-13. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm11226722.