| GIUSEPPE, De Luca, Matteo NARDIN, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura FERRER, Alexandre QUADROS, Marek MILEWSKI, di Uccio Fortunato SCOTTO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA, Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Arpad LUX, Lucia MARINUCCI, Vincenzo GUIDUCCI, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Vincent FLAVIEN, Enrico FABRIS, Inigo Lozano MARTINEZ-LUENGAS, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Joao Antonio Brum SILVEIRA, Rodrigo ZONI, Ivan BESSONOV, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKI, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Giuliana CORTESE, Guido PARODI, Mohammed Abed BOURAGHDA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA and Monica VERDOIA. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic. DIABETES EPIDEMIOLOGY AND MANAGEMENT. AMSTERDAM: ELSEVIER, 2021, vol. 4, October-December 2021, p. 1-9. ISSN 2666-9706. Available from: https://dx.doi.org/10.1016/j.deman.2021.100022. |
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@article{2417950,
author = {Giuseppe, De Luca and Nardin, Matteo and Algowhary, Magdy and Uguz, Berat and Oliveira, Dinaldo C and Ganyukov, Vladimir and Zimbakov, Zan and Cercek, Miha and Jensen, Lisette Okkels and Loh, Poay Huan and Calmac, Lucian and Ferrer, Gerard Roura and Quadros, Alexandre and Milewski, Marek and Scotto, di Uccio Fortunato and Clemens, von Birgelen and Versaci, Francesco and Jurrien, Ten Berg and Casella, Gianni and Lung, Aaron Wong Sung and Kala, Petr and Gil, Jose Luis Diez and Carrillo, Xavier and Dirksen, Maurits and BecerraandMunoz, Victor M and Lee, Michael Kangandyin and Juzar, Dafsah Arifa and Joaquim, Rodrigo de Moura and Paladino, Roberto and Milicic, Davor and Davlouros, Periklis and Bakraceski, Nikola and Zilio, Filippo and Donazzan, Luca and Kraaijeveld, Adriaan and Galasso, Gennaro and Lux, Arpad and Marinucci, Lucia and Guiducci, Vincenzo and Menichelli, Maurizio and Scoccia, Alessandra and Yamac, Aylin Hatice and Mert, Kadir Ugur and Rios, Xacobe Flores and Kovarnik, Tomas and Kidawa, Michal and Moreu, Jose and Flavien, Vincent and Fabris, Enrico and MartinezandLuengas, Inigo Lozano and Boccalatte, Marco and Ojeda, Francisco Bosa and ArellanoandSerrano, Carlos and Caiazzo, Gianluca and Cirrincione, Giuseppe and Kao, HsienandLi and Fores, Juan Sanchis and Vignali, Luigi and Pereira, Helder and Manzo, Stephane and Ordonez, Santiago and Ozkan, Alev Arat and Scheller, Bruno and Lehtola, Heidi and Teles, Rui and Mantis, Christos and Antti, Ylitalo and Silveira, Joao Antonio Brum and Zoni, Rodrigo and Bessonov, Ivan and Savonitto, Stefano and Kochiadakis, George and Alexopulos, Dimitrios and Uribe, Carlos E and Kanakaki, John and Faurie, Benjamin and Gabrielli, Gabriele and Barrios, Alejandro Gutierrez and Bachini, Juan Pablo and Rocha, Alex and Tam, Frankie ChorandCheung and Rodriguez, Alfredo and Lukito, Antonia Anna and SaintandJoy, Veauthyelau and Pessah, Gustavo and Tuccillo, Andrea and Cortese, Giuliana and Parodi, Guido and Bouraghda, Mohammed Abed and Kedhi, Elvin and Lamelas, Pablo and Suryapranata, Harry and Verdoia, Monica},
article_location = {AMSTERDAM},
article_number = {October-December 2021},
doi = {http://dx.doi.org/10.1016/j.deman.2021.100022},
keywords = {renin-angiotensin system inhibitors; diabetic patients; COVID-19},
language = {eng},
issn = {2666-9706},
journal = {DIABETES EPIDEMIOLOGY AND MANAGEMENT},
title = {Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic},
url = {https://www.sciencedirect.com/science/article/pii/S2666970621000226?via%3Dihub},
volume = {4},
year = {2021}
}
TY - JOUR
ID - 2417950
AU - Giuseppe, De Luca - Nardin, Matteo - Algowhary, Magdy - Uguz, Berat - Oliveira, Dinaldo C - Ganyukov, Vladimir - Zimbakov, Zan - Cercek, Miha - Jensen, Lisette Okkels - Loh, Poay Huan - Calmac, Lucian - Ferrer, Gerard Roura - Quadros, Alexandre - Milewski, Marek - Scotto, di Uccio Fortunato - Clemens, von Birgelen - Versaci, Francesco - Jurrien, Ten Berg - Casella, Gianni - Lung, Aaron Wong Sung - Kala, Petr - Gil, Jose Luis Diez - Carrillo, Xavier - Dirksen, Maurits - Becerra-Munoz, Victor M - Lee, Michael Kang-yin - Juzar, Dafsah Arifa - Joaquim, Rodrigo de Moura - Paladino, Roberto - Milicic, Davor - Davlouros, Periklis - Bakraceski, Nikola - Zilio, Filippo - Donazzan, Luca - Kraaijeveld, Adriaan - Galasso, Gennaro - Lux, Arpad - Marinucci, Lucia - Guiducci, Vincenzo - Menichelli, Maurizio - Scoccia, Alessandra - Yamac, Aylin Hatice - Mert, Kadir Ugur - Rios, Xacobe Flores - Kovarnik, Tomas - Kidawa, Michal - Moreu, Jose - Flavien, Vincent - Fabris, Enrico - Martinez-Luengas, Inigo Lozano - Boccalatte, Marco - Ojeda, Francisco Bosa - Arellano-Serrano, Carlos - Caiazzo, Gianluca - Cirrincione, Giuseppe - Kao, Hsien-Li - Fores, Juan Sanchis - Vignali, Luigi - Pereira, Helder - Manzo, Stephane - Ordonez, Santiago - Ozkan, Alev Arat - Scheller, Bruno - Lehtola, Heidi - Teles, Rui - Mantis, Christos - Antti, Ylitalo - Silveira, Joao Antonio Brum - Zoni, Rodrigo - Bessonov, Ivan - Savonitto, Stefano - Kochiadakis, George - Alexopulos, Dimitrios - Uribe, Carlos E - Kanakaki, John - Faurie, Benjamin - Gabrielli, Gabriele - Barrios, Alejandro Gutierrez - Bachini, Juan Pablo - Rocha, Alex - Tam, Frankie Chor-Cheung - Rodriguez, Alfredo - Lukito, Antonia Anna - Saint-Joy, Veauthyelau - Pessah, Gustavo - Tuccillo, Andrea - Cortese, Giuliana - Parodi, Guido - Bouraghda, Mohammed Abed - Kedhi, Elvin - Lamelas, Pablo - Suryapranata, Harry - Verdoia, Monica
PY - 2021
TI - Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic
JF - DIABETES EPIDEMIOLOGY AND MANAGEMENT
VL - 4
IS - October-December 2021
SP - 1-9
EP - 1-9
PB - ELSEVIER
SN - 26669706
KW - renin-angiotensin system inhibitors
KW - diabetic patients
KW - COVID-19
UR - https://www.sciencedirect.com/science/article/pii/S2666970621000226?via%3Dihub
N2 - Background: During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme (ACE)2 and patient's susceptibility to SARS-CoV2 infection. Diabetes mellitus have been recognized favoring the coronavirus infection with consequent increase mortality in COVID-19. No data have been so far reported in diabetic patients suffering from ST-elevation myocardial infarction (STEMI), a very high-risk population deserving of RASI treatment.Methods: The ISACS-STEMI COVID-19 registry retrospectively assessed STEMI patients treated with primary percutaneous coronary intervention (PPCI) in March/June 2019 and 2020 in 109 European high-volume pri-mary PCI centers. This subanalysis assessed the prognostic impact of chronic RASI therapy at admission on mortality and SARS-CoV2 infection among diabetic patients.Results: Our population is represented by 3812 diabetic STEMI patients undergoing mechanical reperfusion, 2038 in 2019 and 1774 in 2020. Among 3761 patients with available data on chronic RASI therapy, between those ones with and without treatment there were several differences in baseline characteristics, (similar in both periods) but no difference in the prevalence of SARS-CoV2 infection (1.6% vs 1.3%, respectively, p = 0.786). Considering in-hospital medication, RASI therapy was overall associated with a significantly lower in-hospital mortality (3.3% vs 15.8%, p < 0.0001), consistently both in 2019 and in 2010.Conclusions: This is first study to investigate the impact of RASI therapy on prognosis and SARS-CoV2 infec-tion of diabetic patients experiencing STEMI and undergoing PPCI during the COVID-19 pandemic. Both pre-admission chronic RASI therapy and in-hospital RASI did not negatively affected patients' survival during the hospitalization, neither increased the risk of SARS-CoV2 infection. Trial registration number: NCT 04412655 (c) 2021 Published by Elsevier Masson SAS.
ER -
GIUSEPPE, De Luca, Matteo NARDIN, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura FERRER, Alexandre QUADROS, Marek MILEWSKI, di Uccio Fortunato SCOTTO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA, Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Arpad LUX, Lucia MARINUCCI, Vincenzo GUIDUCCI, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Vincent FLAVIEN, Enrico FABRIS, Inigo Lozano MARTINEZ-LUENGAS, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Joao Antonio Brum SILVEIRA, Rodrigo ZONI, Ivan BESSONOV, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKI, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Giuliana CORTESE, Guido PARODI, Mohammed Abed BOURAGHDA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA and Monica VERDOIA. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic. \textit{DIABETES EPIDEMIOLOGY AND MANAGEMENT}. AMSTERDAM: ELSEVIER, 2021, vol.~4, October-December 2021, p.~1-9. ISSN~2666-9706. Available from: https://dx.doi.org/10.1016/j.deman.2021.100022.
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