LESKANICOVA, A., M. BABINCAK, F. MOCHNACKY, N. PIPOVA KOKOSOVA, D. KUKELOVA, Nicol URBANSKÁ, M. KOLESAROVA, D. MACEKOVA, J. KOSTOLNY and T. KISKOVA. SEX-DEPENDENT DIFFERENCES IN STRESS- INDUCED DEPRESSION IN WISTAR RATS ARE ACCOMPANIED PREDOMINANTLY BY CHANGES IN PHOSPHATIDYLCHOLINES AND SPHINGOMYELINS. Journal of Physiology and Pharmacology. Krakow: Polish Physiological Society, 2021, vol. 72, No 4, p. 623-635. ISSN 0867-5910. Available from: https://dx.doi.org/10.26402/jpp.2021.4.14.
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Basic information
Original name SEX-DEPENDENT DIFFERENCES IN STRESS- INDUCED DEPRESSION IN WISTAR RATS ARE ACCOMPANIED PREDOMINANTLY BY CHANGES IN PHOSPHATIDYLCHOLINES AND SPHINGOMYELINS
Authors LESKANICOVA, A., M. BABINCAK, F. MOCHNACKY, N. PIPOVA KOKOSOVA, D. KUKELOVA, Nicol URBANSKÁ (703 Slovakia, belonging to the institution), M. KOLESAROVA, D. MACEKOVA, J. KOSTOLNY and T. KISKOVA.
Edition Journal of Physiology and Pharmacology, Krakow, Polish Physiological Society, 2021, 0867-5910.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Poland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.589
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.26402/jpp.2021.4.14
UT WoS 000895980800004
Keywords in English depression; metabolomics; stress; cortisol; adrenocorticotropin hormone; acylcarnitines; phosphatidylcholines; sexdependent; pathogenesis; gender
Tags 14110514, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 11/7/2024 09:45.
Abstract
With a high annual and lifetime prevalence, depression is becoming the leading contributor to the global disease burden. During the COVID-19 crisis, the depression and mood disorders accelerated significantly. Despite the growing evidence, the precise underlying mechanisms of depression disorders (DD) remain unknown. When studying DD in humans, there are many uncontrollable factors such as medication history, age of the patient or living conditions. In this regard, animal models provide an essential step for examining neural circuitry or molecular and cellular pathways in a controlled environment. As far as we know, women have a consistently higher prevalence of DD than men. Thus, the aim of our study was to evaluate sex-related changes in blood metabolites in a model of stress-induced depression in Wistar rats. Pregnant females were stressed using restriction of mobility in the final week of the pregnancy three times a day for 45 minutes each, three following days. After the birth, the progeny aged 60 days was stressed repeatedly. The perturbation in overall energy metabolism as well as in lipid metabolism was found. While in males, phosphatidylcholines (the most phosphatidylcholine with acyl-alkyl residue sum C40:4 - PC ae C40:4), sphingomyelins, and acylcarnitines were changed, in females, lipid metabolism perturbation was seen with the most critical alteration in hydroxysphingomyelin with acyl residue sum C16:1 (SM OH C16:1). Our results confirm that the animal model may be used further in the research of depression. Our results may provide an essential insight into the sex-dependent pathogenesis of depression and contribute to the search for effective treatment and prevention of depression with respect to sex.
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