| WOJTAS, Daniel, Aldona MZYK, Runrun LI, Michael ZEHETBAUER, Erhard SCHAFLER, Anna JARZEBSKA, Bartosz SULKOWSKI and Romana SCHIRHAGL. Verifying the cytotoxicity of a biodegradable zinc alloy with nanodiamond sensors. Biomaterials Advances. AMSTERDAM: Elsevier B.V., 2024, vol. 162, September 2024, p. 1-3, 13 pp. ISSN 2772-9508. Available from: https://dx.doi.org/10.1016/j.bioadv.2024.213927. |
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@article{2418099,
author = {Wojtas, Daniel and Mzyk, Aldona and Li, Runrun and Zehetbauer, Michael and Schafler, Erhard and Jarzebska, Anna and Sulkowski, Bartosz and Schirhagl, Romana},
article_location = {AMSTERDAM},
article_number = {September 2024},
doi = {http://dx.doi.org/10.1016/j.bioadv.2024.213927},
keywords = {Biodegradable zinc; Cytotoxicity; Free radical; Relaxometry; NV center; Nanodiamond},
language = {eng},
issn = {2772-9508},
journal = {Biomaterials Advances},
title = {Verifying the cytotoxicity of a biodegradable zinc alloy with nanodiamond sensors},
url = {https://www.sciencedirect.com/science/article/pii/S2772950824001705?via%3Dihub},
volume = {162},
year = {2024}
}
TY - JOUR
ID - 2418099
AU - Wojtas, Daniel - Mzyk, Aldona - Li, Runrun - Zehetbauer, Michael - Schafler, Erhard - Jarzebska, Anna - Sulkowski, Bartosz - Schirhagl, Romana
PY - 2024
TI - Verifying the cytotoxicity of a biodegradable zinc alloy with nanodiamond sensors
JF - Biomaterials Advances
VL - 162
IS - September 2024
SP - 1-3
EP - 1-3
PB - Elsevier B.V.
SN - 27729508
KW - Biodegradable zinc
KW - Cytotoxicity
KW - Free radical
KW - Relaxometry
KW - NV center
KW - Nanodiamond
UR - https://www.sciencedirect.com/science/article/pii/S2772950824001705?via%3Dihub
N2 - Metals are widely utilized as implant materials for bone fixtures as well as stents. Biodegradable versions of these implants are highly desirable since patients do not have to undergo a second surgery for the materials to be removed. Attractive options for such materials are zinc silver alloys since they also offer the benefit of being antibacterial. However, it is important to investigate the effect of the degradation products of such alloys on the surrounding cells, taking into account silver cytotoxicity. Here we investigated zinc alloyed with 1 % of silver (Zn-1Ag) and how differently concentrated extracts (1 %-100 %) of this material impact human umbilical vein endothelial cells (HUVECs). More specifically, we focused on free radical generation and oxidative stress as well as the impact on cell viability. To determine free radical production we used diamond-based quantum sensing as well as conventional fluorescent assays. The viability was assessed by observing cell morphology and the metabolic activity via the MTT assay. We found that 1 % and 10 % extracts are well tolerated by the cells. However, at higher extract concentrations we observed severe impact on cell viability and oxidative stress. We were also able to show that quantum sensing was able to detect significant free radical generation even at the lowest tested concentrations.
ER -
WOJTAS, Daniel, Aldona MZYK, Runrun LI, Michael ZEHETBAUER, Erhard SCHAFLER, Anna JARZEBSKA, Bartosz SULKOWSKI and Romana SCHIRHAGL. Verifying the cytotoxicity of a biodegradable zinc alloy with nanodiamond sensors. \textit{Biomaterials Advances}. AMSTERDAM: Elsevier B.V., 2024, vol.~162, September 2024, p.~1-3, 13 pp. ISSN~2772-9508. Available from: https://dx.doi.org/10.1016/j.bioadv.2024.213927.
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