Other formats:
BibTeX
LaTeX
RIS
@article{2418602,
author = {Theis, Hendrik and Pavese, Nicola and Rektorová, Irena and Eimeren, Thilo van},
article_location = {AMSTERDAM},
doi = {http://dx.doi.org/10.3233/JPD-230385},
language = {eng},
issn = {1877-7171},
journal = {Journal of Parkinson's disease},
title = {Imaging Biomarkers in Prodromal and Earliest Phases of Parkinson's Disease},
url = {https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd230385},
year = {2024}
}
TY - JOUR
ID - 2418602
AU - Theis, Hendrik - Pavese, Nicola - Rektorová, Irena - Eimeren, Thilo van
PY - 2024
TI - Imaging Biomarkers in Prodromal and Earliest Phases of Parkinson's Disease
JF - Journal of Parkinson's disease
PB - IOS PRESS
SN - 18777171
UR - https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd230385
N2 - Assessing imaging biomarker in the prodromal and early phases of Parkinson’s disease (PD) is of great importance to ensure an early and safe diagnosis. In the last decades, imaging modalities advanced and are now able to assess many different aspects of neurodegeneration in PD. MRI sequences can measure iron content or neuromelanin. Apart from SPECT imaging with Ioflupane, more specific PET tracers to assess degeneration of the dopaminergic system are available. Furthermore, metabolic PET patterns can be used to anticipate a phenoconversion from prodromal PD to manifest PD. In this regard, it is worth mentioning that PET imaging of inflammation will gain significance. Molecular imaging of neurotransmitters like serotonin, noradrenaline and acetylcholine shed more light on non-motor symptoms. Outside of the brain, molecular imaging of the heart and gut is used to measure PD-related degeneration of the autonomous nervous system. Moreover, optical coherence tomography can noninvasively detect degeneration of retinal fibers as a potential biomarker in PD. In this review, we describe these state-of-the-art imaging modalities in early and prodromal PD and point out in how far these techniques can and will be used in the future to pave the way towards a biomarker-based staging of PD.
ER -
THEIS, Hendrik, Nicola PAVESE, Irena REKTOROVÁ and Thilo van EIMEREN. Imaging Biomarkers in Prodromal and Earliest Phases of Parkinson's Disease. \textit{Journal of Parkinson's disease}. AMSTERDAM: IOS PRESS, 2024. ISSN~1877-7171. Available from: https://dx.doi.org/10.3233/JPD-230385.
|
