High frequency oscillations in human memory and cognition: a
neurophysiological substrate of engrams?

J 2024

High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?

KUCEWICZ, Michal T, Jan CIMBÁLNÍK, Jesus S S GARCIA, Milan BRÁZDIL, Gregory A WORRELL et. al.

Basic information

Original name

High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?

Authors

KUCEWICZ, Michal T, Jan CIMBÁLNÍK, Jesus S S GARCIA, Milan BRÁZDIL and Gregory A WORRELL

Edition

Brain, OXFORD, OXFORD UNIV PRESS, 2024, 0006-8950

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 14.500 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/brain/awae159

UT WoS

999

Keywords in English

network oscillations; intracranial EEG; local field potential; cognition; sharp-wave ripples; memory consolidation

Abstract

V originále

Despite advances in understanding the cellular and molecular processes underlying memory and cognition, and recent successful modulation of cognitive performance in brain disorders, the neurophysiological mechanisms remain underexplored. High frequency oscillations beyond the classic electroencephalogram spectrum have emerged as a potential neural correlate of fundamental cognitive processes. High frequency oscillations are detected in the human mesial temporal lobe and neocortical intracranial recordings spanning gamma/epsilon (60-150 Hz), ripple (80-250 Hz) and higher frequency ranges. Separate from other non-oscillatory activities, these brief electrophysiological oscillations of distinct duration, frequency and amplitude are thought to be generated by coordinated spiking of neuronal ensembles within volumes as small as a single cortical column. Although the exact origins, mechanisms, and physiological roles in health and disease remain elusive, they have been associated with human memory consolidation and cognitive processing. Recent studies suggest their involvement in encoding and recall of episodic memory with a possible role in the formation and reactivation of memory traces. High frequency oscillations are detected during encoding, throughout maintenance, and right before recall of remembered items, meeting a basic definition for an engram activity. The temporal coordination of high frequency oscillations reactivated across cortical and subcortical neural networks is ideally suited for integrating multimodal memory representations, which can be replayed and consolidated during states of wakefulness and sleep. High frequency oscillations have been shown to reflect coordinated bursts of neuronal assembly firing and offer a promising substrate for tracking and modulation of the hypothetical electrophysiological engram.

Citovat

KUCEWICZ, Michal T, Jan CIMBÁLNÍK, Jesus S S GARCIA, Milan BRÁZDIL and Gregory A WORRELL. High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams? Brain. OXFORD: OXFORD UNIV PRESS, 2024. ISSN 0006-8950. Available from: https://dx.doi.org/10.1093/brain/awae159.

@article{2418603,
   author = {Kucewicz, Michal T and Cimbálník, Jan and Garcia, Jesus S S and Brázdil, Milan and Worrell, Gregory A},
   article_location = {OXFORD},
   doi = {http://dx.doi.org/10.1093/brain/awae159},
   keywords = {network oscillations; intracranial EEG; local field potential; cognition; sharp-wave ripples; memory consolidation},
   language = {eng},
   issn = {0006-8950},
   journal = {Brain},
   title = {High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?},
   url = {https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae159/7672954?login=true},
   year = {2024}
}

TY  - JOUR
ID  - 2418603
AU  - Kucewicz, Michal T - Cimbálník, Jan - Garcia, Jesus S S - Brázdil, Milan - Worrell, Gregory A
PY  - 2024
TI  - High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?
JF  - Brain
PB  - OXFORD UNIV PRESS
SN  - 00068950
KW  - network oscillations
KW  - intracranial EEG
KW  - local field potential
KW  - cognition
KW  - sharp-wave ripples
KW  - memory consolidation
UR  - https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae159/7672954?login=true
N2  - Despite advances in understanding the cellular and molecular processes underlying memory and cognition, and recent successful modulation of cognitive performance in brain disorders, the neurophysiological mechanisms remain underexplored. High frequency oscillations beyond the classic electroencephalogram spectrum have emerged as a potential neural correlate of fundamental cognitive processes. High frequency oscillations are detected in the human mesial temporal lobe and neocortical intracranial recordings spanning gamma/epsilon (60-150 Hz), ripple (80-250 Hz) and higher frequency ranges. Separate from other non-oscillatory activities, these brief electrophysiological oscillations of distinct duration, frequency and amplitude are thought to be generated by coordinated spiking of neuronal ensembles within volumes as small as a single cortical column. Although the exact origins, mechanisms, and physiological roles in health and disease remain elusive, they have been associated with human memory consolidation and cognitive processing. Recent studies suggest their involvement in encoding and recall of episodic memory with a possible role in the formation and reactivation of memory traces. High frequency oscillations are detected during encoding, throughout maintenance, and right before recall of remembered items, meeting a basic definition for an engram activity. The temporal coordination of high frequency oscillations reactivated across cortical and subcortical neural networks is ideally suited for integrating multimodal memory representations, which can be replayed and consolidated during states of wakefulness and sleep. High frequency oscillations have been shown to reflect coordinated bursts of neuronal assembly firing and offer a promising substrate for tracking and modulation of the hypothetical electrophysiological engram.
ER  -

KUCEWICZ, Michal T, Jan CIMBÁLNÍK, Jesus S S GARCIA, Milan BRÁZDIL and Gregory A WORRELL. High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams? \textit{Brain}. OXFORD: OXFORD UNIV PRESS, 2024. ISSN~0006-8950. Available from: https://dx.doi.org/10.1093/brain/awae159.

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