Prenatal exposure to air pollution and maternal depression:
Combined effects on brain aging and mental health in young
adulthood

J 2024

Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL, Klára MAREČKOVÁ et. al.

Basic information

Original name

Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood

Authors

JÁNI, Martin (703 Slovakia, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Klára MAREČKOVÁ (203 Czech Republic, belonging to the institution)

Edition

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2024, 0278-5846

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600 in 2022

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.pnpbp.2024.111062

UT WoS

001258873600001

Keywords in English

Air pollution; Maternal antenatal depression; Brain aging; Longitudinal; Prenatal birth cohort

Abstract

V originále

Introduction: Both maternal depression problems during pregnancy and prenatal exposure to air pollution have been associated with changes in the brain as well as worse mood and anxiety in the offspring in adulthood. However, it is not clear whether these effects are independent or whether and how they might interact and impact the brain age and mental health of the young adult offspring. Methods: A total of 202 mother-child dyads from a prenatal birth cohort were assessed for maternal depression during pregnancy through self-report questionnaires administered in the early 90s, exposure to air pollutants (Sulfur dioxide [SO2], nitrogen oxides [NOx], and suspended particle matter [SPM]) during each trimester based on maternal address and air quality data, mental health of the young adult offspring (28-30 years of age; 52% men, all of European ancestry) using self-report questionnaires for depression (Beck Depression Inventory), mood dysregulation (Profile of Mood States), anxiety (State-Trait Anxiety Inventory), and psychotic symptoms (Schizotypal Personality Questionnaire), and brain age, estimated from structural magnetic resonance imaging (MRI) and previously published neuroanatomical age prediction model using cortical thickness maps. The brain age gap estimate (BrainAGE) was computed by subtracting structural brain age from chronological age. Trajectories of exposure to air pollution during pregnancy were assessed using Growth Mixture Modeling. The interactions of prenatal depression and prenatal exposure to air pollutants on adult mental health and BrainAGE were assessed using hierarchical linear regression. Results: We revealed two distinct trajectories of exposure to air pollution during pregnancy: "early exposure," characterized by high exposure during the first trimester, followed by a steady decrease, and "late exposure," characterized by low exposure during the first trimester, followed by a steady increase in the exposure during the subsequent trimesters. Maternal depression during the first half of pregnancy interacted with NOX exposure trajectory, predicting mood dysregulation and schizotypal symptoms in young adults. In addition, maternal depression during the second half of pregnancy interacted with both NOx and SO2 exposure trajectories, respectively, and predicted BrainAGE in young adults. In those with early exposure to NOx, maternal depression during pregnancy was associated with worse mental health and accelerated brain aging in young adulthood. In contrast, in those with early exposure to SO2, maternal depression during pregnancy was associated with slower brain aging in young adulthood. Conclusions: Our findings provide the first evidence of the combined effects of prenatal exposure to air pollution and maternal depression on mental health outcomes and brain age in young adult offspring. Moreover, they point out the importance of the timing and trajectory of the exposure during prenatal development.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LX22NPO5107, research and development project

Name: Národní ústav pro neurologický výzkum

Investor: Ministry of Education, Youth and Sports of the CR, 5.1 EXCELES

NU20J-04-00022, research and development project

Name: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministry of Health of the CR, Healthy Brain Ageing in Czechia over the life-course, Subprogram 2 - junior

Citovat

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL and Klára MAREČKOVÁ. Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2024, vol. 134, August 2024, p. 1-8. ISSN 0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2024.111062.

@article{2418605,
   author = {Jáni, Martin and Mikeš, Ondřej and Mareček, Radek and Brázdil, Milan and Marečková, Klára},
   article_location = {OXFORD},
   article_number = {August 2024},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2024.111062},
   keywords = {Air pollution; Maternal antenatal depression; Brain aging; Longitudinal; Prenatal birth cohort},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY},
   title = {Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584624001301?via%3Dihub},
   volume = {134},
   year = {2024}
}

TY  - JOUR
ID  - 2418605
AU  - Jáni, Martin - Mikeš, Ondřej - Mareček, Radek - Brázdil, Milan - Marečková, Klára
PY  - 2024
TI  - Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY
VL  - 134
IS  - August 2024
SP  - 1-8
EP  - 1-8
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Air pollution
KW  - Maternal antenatal depression
KW  - Brain aging
KW  - Longitudinal
KW  - Prenatal birth cohort
UR  - https://www.sciencedirect.com/science/article/pii/S0278584624001301?via%3Dihub
N2  - Introduction: Both maternal depression problems during pregnancy and prenatal exposure to air pollution have been associated with changes in the brain as well as worse mood and anxiety in the offspring in adulthood. However, it is not clear whether these effects are independent or whether and how they might interact and impact the brain age and mental health of the young adult offspring. Methods: A total of 202 mother-child dyads from a prenatal birth cohort were assessed for maternal depression during pregnancy through self-report questionnaires administered in the early 90s, exposure to air pollutants (Sulfur dioxide [SO2], nitrogen oxides [NOx], and suspended particle matter [SPM]) during each trimester based on maternal address and air quality data, mental health of the young adult offspring (28-30 years of age; 52% men, all of European ancestry) using self-report questionnaires for depression (Beck Depression Inventory), mood dysregulation (Profile of Mood States), anxiety (State-Trait Anxiety Inventory), and psychotic symptoms (Schizotypal Personality Questionnaire), and brain age, estimated from structural magnetic resonance imaging (MRI) and previously published neuroanatomical age prediction model using cortical thickness maps. The brain age gap estimate (BrainAGE) was computed by subtracting structural brain age from chronological age. Trajectories of exposure to air pollution during pregnancy were assessed using Growth Mixture Modeling. The interactions of prenatal depression and prenatal exposure to air pollutants on adult mental health and BrainAGE were assessed using hierarchical linear regression. Results: We revealed two distinct trajectories of exposure to air pollution during pregnancy: "early exposure," characterized by high exposure during the first trimester, followed by a steady decrease, and "late exposure," characterized by low exposure during the first trimester, followed by a steady increase in the exposure during the subsequent trimesters. Maternal depression during the first half of pregnancy interacted with NOX exposure trajectory, predicting mood dysregulation and schizotypal symptoms in young adults. In addition, maternal depression during the second half of pregnancy interacted with both NOx and SO2 exposure trajectories, respectively, and predicted BrainAGE in young adults. In those with early exposure to NOx, maternal depression during pregnancy was associated with worse mental health and accelerated brain aging in young adulthood. In contrast, in those with early exposure to SO2, maternal depression during pregnancy was associated with slower brain aging in young adulthood. Conclusions: Our findings provide the first evidence of the combined effects of prenatal exposure to air pollution and maternal depression on mental health outcomes and brain age in young adult offspring. Moreover, they point out the importance of the timing and trajectory of the exposure during prenatal development.
ER  -

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL and Klára MAREČKOVÁ. Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{}BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2024, vol.~134, August 2024, p.~1-8. ISSN~0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2024.111062.

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