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@article{2418613,
author = {Lietava, Samuel and Sepši, Milan and Zídková, Jana and Synková, Iva and Kozák, Milan and Křivan, Lubomír and Vlašínová, Jitka and Richter, Svatopluk and Rehor, Jan and Kala, Petr and Bébarová, Markéta and Novotný, Tomáš},
article_location = {BERLIN},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting},
url = {https://www.nature.com/articles/s41598-024-64513-7},
year = {2024}
}
TY - JOUR
ID - 2418613
AU - Lietava, Samuel - Sepši, Milan - Zídková, Jana - Synková, Iva - Kozák, Milan - Křivan, Lubomír - Vlašínová, Jitka - Richter, Svatopluk - Rehor, Jan - Kala, Petr - Bébarová, Markéta - Novotný, Tomáš
PY - 2024
TI - The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting
JF - Scientific Reports
PB - NATURE PORTFOLIO
SN - 20452322
UR - https://www.nature.com/articles/s41598-024-64513-7
N2 - Traditionally, aborted cardiac arrest (ACA) due to documented ventricular fibrillation (VF) in the absence of structural heart disease has been termed idiopathic VF. By careful evaluation, a specific etiology can be found in a substantial proportion of patients. The aim of this survey was to assess the yield of an advanced diagnostic work-up to reveal a causative etiology in a real-life clinical setting. Patients from the University Hospital Brno’s ACA database were analyzed (514 patients in total). Forty-six patients (31 males) fulfilled the inclusion criteria, which were: (1) absence of structural pathology on echocardiography; (2) absence of coronary artery disease; and (3) absence of reversible cause of ACA. The diagnostic work-up consisted in cardiac magnetic resonance imaging, stress testing, sodium channel blocker challenge, and genetic testing according to the availability of the method and patient compliance. A specific disease was found in 17 individuals (37.0%), although at least one diagnostic step was refused by 13 patients (28.3%). True idiopathic VF was confirmed in 7 patients (15.2%), for whom the entire diagnostic work-up did not reveal any specific pathology. Our real-life survey shows that, even with an incomplete diagnostic work-up (due to the unavailability of a particular method or variable patient compliance), a specific diagnosis can be identified in more than one third of the cases of “idiopathic” VF, which can thus enable targeted treatment and family screening.
ER -
LIETAVA, Samuel, Milan SEPŠI, Jana ZÍDKOVÁ, Iva SYNKOVÁ, Milan KOZÁK, Lubomír KŘIVAN, Jitka VLAŠÍNOVÁ, Svatopluk RICHTER, Jan REHOR, Petr KALA, Markéta BÉBAROVÁ and Tomáš NOVOTNÝ. The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting. \textit{Scientific Reports}. BERLIN: NATURE PORTFOLIO, 2024. ISSN~2045-2322.
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