The yield of a comprehensive investigation protocol for the
diagnosis of true idiopathic ventricular fibrillation in a
real-life clinical setting

J 2024

The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting

LIETAVA, Samuel, Milan SEPŠI, Jana ZÍDKOVÁ, Iva SYNKOVÁ, Milan KOZÁK et. al.

Basic information

Original name

The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting

Authors

LIETAVA, Samuel (703 Slovakia, belonging to the institution), Milan SEPŠI (203 Czech Republic, belonging to the institution), Jana ZÍDKOVÁ (203 Czech Republic, belonging to the institution), Iva SYNKOVÁ (203 Czech Republic, belonging to the institution), Milan KOZÁK (203 Czech Republic, belonging to the institution), Lubomír KŘIVAN (203 Czech Republic, belonging to the institution), Jitka VLAŠÍNOVÁ (203 Czech Republic, belonging to the institution), Svatopluk RICHTER (203 Czech Republic, belonging to the institution), Jan REHOR (203 Czech Republic), Petr KALA (203 Czech Republic, belonging to the institution), Markéta BÉBAROVÁ (203 Czech Republic, belonging to the institution) and Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution)

Edition

Scientific Reports, BERLIN, NATURE PORTFOLIO, 2024, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-024-64513-7

UT WoS

001314381900048

Keywords in English

Idiopathic ventricular fibrillation; Diagnostic protocol

Abstract

V originále

Traditionally, aborted cardiac arrest (ACA) due to documented ventricular fibrillation (VF) in the absence of structural heart disease has been termed idiopathic VF. By careful evaluation, a specific etiology can be found in a substantial proportion of patients. The aim of this survey was to assess the yield of an advanced diagnostic work-up to reveal a causative etiology in a real-life clinical setting. Patients from the University Hospital Brno’s ACA database were analyzed (514 patients in total). Forty-six patients (31 males) fulfilled the inclusion criteria, which were: (1) absence of structural pathology on echocardiography; (2) absence of coronary artery disease; and (3) absence of reversible cause of ACA. The diagnostic work-up consisted in cardiac magnetic resonance imaging, stress testing, sodium channel blocker challenge, and genetic testing according to the availability of the method and patient compliance. A specific disease was found in 17 individuals (37.0%), although at least one diagnostic step was refused by 13 patients (28.3%). True idiopathic VF was confirmed in 7 patients (15.2%), for whom the entire diagnostic work-up did not reveal any specific pathology. Our real-life survey shows that, even with an incomplete diagnostic work-up (due to the unavailability of a particular method or variable patient compliance), a specific diagnosis can be identified in more than one third of the cases of “idiopathic” VF, which can thus enable targeted treatment and family screening.

Links

NU22-02-00348, research and development project

Name: Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus

Investor: Ministry of Health of the CR, Subprogram 1 - standard

Citovat

LIETAVA, Samuel, Milan SEPŠI, Jana ZÍDKOVÁ, Iva SYNKOVÁ, Milan KOZÁK, Lubomír KŘIVAN, Jitka VLAŠÍNOVÁ, Svatopluk RICHTER, Jan REHOR, Petr KALA, Markéta BÉBAROVÁ and Tomáš NOVOTNÝ. The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting. Scientific Reports. BERLIN: NATURE PORTFOLIO, 2024, vol. 14, No 1, p. 1-8. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-024-64513-7.

@article{2418613,
   author = {Lietava, Samuel and Sepši, Milan and Zídková, Jana and Synková, Iva and Kozák, Milan and Křivan, Lubomír and Vlašínová, Jitka and Richter, Svatopluk and Rehor, Jan and Kala, Petr and Bébarová, Markéta and Novotný, Tomáš},
   article_location = {BERLIN},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-024-64513-7},
   keywords = {Idiopathic ventricular fibrillation; Diagnostic protocol},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting},
   url = {https://www.nature.com/articles/s41598-024-64513-7},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2418613
AU  - Lietava, Samuel - Sepši, Milan - Zídková, Jana - Synková, Iva - Kozák, Milan - Křivan, Lubomír - Vlašínová, Jitka - Richter, Svatopluk - Rehor, Jan - Kala, Petr - Bébarová, Markéta - Novotný, Tomáš
PY  - 2024
TI  - The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting
JF  - Scientific Reports
VL  - 14
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - NATURE PORTFOLIO
SN  - 20452322
KW  - Idiopathic ventricular fibrillation
KW  - Diagnostic protocol
UR  - https://www.nature.com/articles/s41598-024-64513-7
N2  - Traditionally, aborted cardiac arrest (ACA) due to documented ventricular fibrillation (VF) in the absence of structural heart disease has been termed idiopathic VF. By careful evaluation, a specific etiology can be found in a substantial proportion of patients. The aim of this survey was to assess the yield of an advanced diagnostic work-up to reveal a causative etiology in a real-life clinical setting. Patients from the University Hospital Brno’s ACA database were analyzed (514 patients in total). Forty-six patients (31 males) fulfilled the inclusion criteria, which were: (1) absence of structural pathology on echocardiography; (2) absence of coronary artery disease; and (3) absence of reversible cause of ACA. The diagnostic work-up consisted in cardiac magnetic resonance imaging, stress testing, sodium channel blocker challenge, and genetic testing according to the availability of the method and patient compliance. A specific disease was found in 17 individuals (37.0%), although at least one diagnostic step was refused by 13 patients (28.3%). True idiopathic VF was confirmed in 7 patients (15.2%), for whom the entire diagnostic work-up did not reveal any specific pathology. Our real-life survey shows that, even with an incomplete diagnostic work-up (due to the unavailability of a particular method or variable patient compliance), a specific diagnosis can be identified in more than one third of the cases of “idiopathic” VF, which can thus enable targeted treatment and family screening.
ER  -

LIETAVA, Samuel, Milan SEPŠI, Jana ZÍDKOVÁ, Iva SYNKOVÁ, Milan KOZÁK, Lubomír KŘIVAN, Jitka VLAŠÍNOVÁ, Svatopluk RICHTER, Jan REHOR, Petr KALA, Markéta BÉBAROVÁ and Tomáš NOVOTNÝ. The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting. \textit{Scientific Reports}. BERLIN: NATURE PORTFOLIO, 2024, vol.~14, No~1, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-024-64513-7.

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