Detailed Information on Publication Record
2022
COMBINED LOCAL TREATMENT OF BRAIN METASTASES: SURGERY AND POSTOPERATIVE STEREOTACTIC RADIOTHERAPY
FADRUS, Pavel, Václav VYBÍHAL, Vilém JURÁŇ, Ivana ROŠKOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ et. al.Basic information
Original name
COMBINED LOCAL TREATMENT OF BRAIN METASTASES: SURGERY AND POSTOPERATIVE STEREOTACTIC RADIOTHERAPY
Authors
FADRUS, Pavel (203 Czech Republic), Václav VYBÍHAL (203 Czech Republic), Vilém JURÁŇ (203 Czech Republic), Ivana ROŠKOVÁ (703 Slovakia), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Czech Republic), Tereza KOPŘIVOVÁ (203 Czech Republic), Miloš KEŘKOVSKÝ (203 Czech Republic), Radek LAKOMÝ (203 Czech Republic), Tomáš KAZDA (203 Czech Republic), Ludmila HYNKOVÁ (203 Czech Republic), Renata BELANOVÁ (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic), Radim JANČÁLEK (203 Czech Republic), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic) and Martin SMRČKA (203 Czech Republic)
Edition
27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), 2022
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30204 Oncology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Central European Institute of Technology
UT WoS
000888571001288
Keywords in English
BRAIN METASTASES; COMBINED LOCAL TREATMENT
Tags
International impact
Změněno: 31/7/2024 13:47, Mgr. Tereza Miškechová
Abstract
V originále
INTRODUCTION: Modern comprehensive local treatment of BM provides the possibility of adequate local control while maintaining a satisfactory quality of life. METHODS: Patients after metastasectomy and postoperative radiotherapy treated between 2007-2020 were evaluated. Local control was assessed separately at the site of the operated MM (localPFS) and separately in other parts of the brain (distalPFS). RESULTS: A total of 118 patients were enrolled (70 with WBRT), 54% were women, the median age was 60 years, the median performance status Karnofsky 80%. The most common primary tumor was lung carcinoma (39/118, 33%). Targeted stereotactic radiotherapy was significantly more often indicated in operations performed after 2016 (p < 0.001). In the period 2013-2019, gross total resection was achieved significantly more often (83 vs 64%; p = 0.061). The median follow-up is 49 months. The median overall survival (OS) is 9 months (6.2 - 12), the median localPFS 22 months (14 - unattainable), median distPFS 11 months (6.8 - 27 months), median extracranialPFS 11 months (5.9 - 15). Stratification of patients according to the prognostic index brainmetgpa.com led to significant separation of patients for OS (p = 0.00017). In a multivariate analysis, stereotactic radiotherapy was statistically significant positive prognostic factor for OS compared to WBRT (median OS 17 vs. 5.6 months, HR 0.59, p = 0.018) with no effect on localPFS. CONCLUSION: Our results of comprehensive local treatment of BM are comparable with the results presented by important foreign studies from prestigious oncology centers. We described targeted stereotactic postoperative radiotherapy as an independent positive prognostic factor after brain metastasectomy.
Links
| NV18-03-00398, research and development project |
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| NV19-03-00501, research and development project |
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| NV19-03-00559, research and development project |
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