| TURANEK, Jaroslav, Petr KOSZTYU, Pavlina TURANEK KNOTIGOVA, Eliska BARTHELDYOVA, Frantisek HUBATKA, Nikola ODEHNALOVA, Robert MIKULÍK, Naděžda VAŠKOVICOVÁ, Hana ČELECHOVSKÁ, Irena KRATOCHVILOVA, Ladislav FEKETE, Marina R. TAVARES, Petr CHYTIL, Milan RASKA and Tomas ETRYCH. Long circulating liposomal platform utilizing hydrophilic polymer-based surface modification: preparation, characterisation, and biological evaluation. International Journal of Pharmaceutics. AMSTERDAM: ELSEVIER, 2024, vol. 661, August 2024, p. 1-14. ISSN 0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2024.124465. |
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@article{2421640,
author = {Turanek, Jaroslav and Kosztyu, Petr and Turanek Knotigova, Pavlina and Bartheldyova, Eliska and Hubatka, Frantisek and Odehnalova, Nikola and Mikulík, Robert and Vaškovicová, Naděžda and Čelechovská, Hana and Kratochvilova, Irena and Fekete, Ladislav and Tavares, Marina R. and Chytil, Petr and Raska, Milan and Etrych, Tomas},
article_location = {AMSTERDAM},
article_number = {August 2024},
doi = {http://dx.doi.org/10.1016/j.ijpharm.2024.124465},
keywords = {Stealth liposomes; HPMA copolymer; Complement activation; Drug delivery system; Long-circulating liposomes},
language = {eng},
issn = {0378-5173},
journal = {International Journal of Pharmaceutics},
title = {Long circulating liposomal platform utilizing hydrophilic polymer-based surface modification: preparation, characterisation, and biological evaluation},
url = {https://www.sciencedirect.com/science/article/pii/S0378517324006999?via%3Dihub},
volume = {661},
year = {2024}
}
TY - JOUR
ID - 2421640
AU - Turanek, Jaroslav - Kosztyu, Petr - Turanek Knotigova, Pavlina - Bartheldyova, Eliska - Hubatka, Frantisek - Odehnalova, Nikola - Mikulík, Robert - Vaškovicová, Naděžda - Čelechovská, Hana - Kratochvilova, Irena - Fekete, Ladislav - Tavares, Marina R. - Chytil, Petr - Raska, Milan - Etrych, Tomas
PY - 2024
TI - Long circulating liposomal platform utilizing hydrophilic polymer-based surface modification: preparation, characterisation, and biological evaluation
JF - International Journal of Pharmaceutics
VL - 661
IS - August 2024
SP - 1-14
EP - 1-14
PB - ELSEVIER
SN - 03785173
KW - Stealth liposomes
KW - HPMA copolymer
KW - Complement activation
KW - Drug delivery system
KW - Long-circulating liposomes
UR - https://www.sciencedirect.com/science/article/pii/S0378517324006999?via%3Dihub
N2 - Liposomes are one of the most important drug delivery vectors, nowadays used in clinics. In general, polyethylene glycol (PEG) is used to ensure the stealth properties of the liposomes. Here, we have employed hydrophilic, biocompatible and highly non-fouling N-(2-hydroxypropyl) methacrylamide (HPMA)-based copolymers containing hydrophobic cholesterol anchors for the surface modification of liposomes, which were prepared by the method of lipid film hydration and extrusion through 100 nm polycarbonate filters. Efficient surface modification of liposomes was confirmed by transmission electron microscopy, atomic force microscopy, and gradient ultracentrifugation. The ability of long-term circulation in the vascular bed was demonstrated in rabbits after i.v. application of fluorescently labelled liposomes. Compared to PEGylated liposomes, HPMA-based copolymer-modified liposomes did not induce specific antibody formation and did not activate murine and human complement. Compared with PEGylated liposomes, HPMA-based copolymer-modified liposomes showed a better long-circulating effect after repeated administration. HPMA-based copolymer-modified liposomes thus represent suitable new candidates for a generation of safer and improved liposomal drug delivery platforms.
ER -
TURANEK, Jaroslav, Petr KOSZTYU, Pavlina TURANEK KNOTIGOVA, Eliska BARTHELDYOVA, Frantisek HUBATKA, Nikola ODEHNALOVA, Robert MIKULÍK, Naděžda VAŠKOVICOVÁ, Hana ČELECHOVSKÁ, Irena KRATOCHVILOVA, Ladislav FEKETE, Marina R. TAVARES, Petr CHYTIL, Milan RASKA and Tomas ETRYCH. Long circulating liposomal platform utilizing hydrophilic polymer-based surface modification: preparation, characterisation, and biological evaluation. \textit{International Journal of Pharmaceutics}. AMSTERDAM: ELSEVIER, 2024, vol.~661, August 2024, p.~1-14. ISSN~0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2024.124465.
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