Factors affecting mortality in COVID-19-associated pulmonary
aspergillosis: An international ID-IRI study

J 2024

Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study

SAHIN, Meyha, Mesut YILMAZ, Ali MERT, Ahmet Naci EMECEN, Muna A Rahman S. AL MASLAMANI et. al.

Basic information

Original name

Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study

Authors

SAHIN, Meyha, Mesut YILMAZ, Ali MERT, Ahmet Naci EMECEN, Muna A Rahman S. AL MASLAMANI, Samar Mahmoud A HASHIM, Ajithkumar Valooparambil ITTAMAN, Al Ramahi Jamal WADI, Balint Gergely SZABO, Deborah KONOPNICKI, Dilsah Baskol ELIK, Botond LAKATOS, Oguz Resat SIPAHI, Reham KHEDR, Sabah JALAL, Natalia PSHENICHNAYA, Dumitru Irina MAGDALENA, Amani EL-KHOLY, Ejaz Ahmed KHAN, Sevil ALKAN, Atousa HAKAMIFARD, Gulden SINCAN, Aliye ESMAOGLU, Mateja Jankovic MAKEK, Esra GURBUZ, Anna LISKOVA, Ayse ALBAYRAK, Roman STEBEL (203 Czech Republic, belonging to the institution), Tulay Unver ULUSOY, Rezaul Karim RIPON, Ruxandra MOROTI, Cosmin DASCALU, Naveed RASHID, Andrea CORTEGIANI, Zeynep BAHAD and Hakan ERDEM

Edition

Heliyon, CAMBRIDGE, CELL PRESS, 2024, 2405-8440

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.000 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.heliyon.2024.e34325

UT WoS

001272308400001

Keywords in English

COVID-19; COVID-19-associated aspergillosis; Intensive care unit; Mortality

Abstract

V originále

Background: This study aimed to identify factors that influence the mortality rate of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA). Methods: In this cross-sectional study, data from 23 centers across 15 countries, spanning the period of March 2020 to December 2021, were retrospectively collected. The study population comprised patients who developed invasive pulmonary aspergillosis while being treated for COVID-19 in the intensive care unit. Cox regression and decision tree analyses were used to identify factors associated with mortality in patients with CAPA. Results: A total of 162 patients (males, 65.4 %; median age: 64 [25th-75th: 54.0-73.8] years) were included in the study, of whom 113 died during the 90-day follow-up period. The median duration from CAPA diagnosis to death was 12 (25th-75th: 7-19) days. In the multivariable Cox regression model, an age of >= 65 years (hazard ratio [HR]: 2.05, 95 % confidence interval [CI]: 1.37-3.07), requiring vasopressor therapy at the time of CAPA diagnosis (HR: 1.80, 95 % CI: 1.17-2.76), and receiving renal replacement therapy at the time of CAPA diagnosis (HR: 2.27, 95 % CI: 1.35-3.82) were identified as predictors of mortality. Decision tree analysis revealed that patients with CAPA aged >= 65 years who received corticosteroid treatment for COVID-19 displayed higher mortality rates (estimated rate: 1.6, observed in 46 % of patients). Conclusion: This study concluded that elderly patients with CAPA who receive corticosteroids are at a significantly higher risk of mortality, particularly if they experience multiorgan failure.

Citovat

SAHIN, Meyha, Mesut YILMAZ, Ali MERT, Ahmet Naci EMECEN, Muna A Rahman S. AL MASLAMANI, Samar Mahmoud A HASHIM, Ajithkumar Valooparambil ITTAMAN, Al Ramahi Jamal WADI, Balint Gergely SZABO, Deborah KONOPNICKI, Dilsah Baskol ELIK, Botond LAKATOS, Oguz Resat SIPAHI, Reham KHEDR, Sabah JALAL, Natalia PSHENICHNAYA, Dumitru Irina MAGDALENA, Amani EL-KHOLY, Ejaz Ahmed KHAN, Sevil ALKAN, Atousa HAKAMIFARD, Gulden SINCAN, Aliye ESMAOGLU, Mateja Jankovic MAKEK, Esra GURBUZ, Anna LISKOVA, Ayse ALBAYRAK, Roman STEBEL, Tulay Unver ULUSOY, Rezaul Karim RIPON, Ruxandra MOROTI, Cosmin DASCALU, Naveed RASHID, Andrea CORTEGIANI, Zeynep BAHAD and Hakan ERDEM. Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study. Heliyon. CAMBRIDGE: CELL PRESS, 2024, vol. 10, No 14, p. 1-11. ISSN 2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2024.e34325.

@article{2421642,
   author = {Sahin, Meyha and Yilmaz, Mesut and Mert, Ali and Emecen, Ahmet Naci and Al Maslamani, Muna A Rahman S. and Hashim, Samar Mahmoud A and Ittaman, Ajithkumar Valooparambil and Wadi, Al Ramahi Jamal and Szabo, Balint Gergely and Konopnicki, Deborah and Elik, Dilsah Baskol and Lakatos, Botond and Sipahi, Oguz Resat and Khedr, Reham and Jalal, Sabah and Pshenichnaya, Natalia and Magdalena, Dumitru Irina and ElandKholy, Amani and Khan, Ejaz Ahmed and Alkan, Sevil and Hakamifard, Atousa and Sincan, Gulden and Esmaoglu, Aliye and Makek, Mateja Jankovic and Gurbuz, Esra and Liskova, Anna and Albayrak, Ayse and Stebel, Roman and Ulusoy, Tulay Unver and Ripon, Rezaul Karim and Moroti, Ruxandra and Dascalu, Cosmin and Rashid, Naveed and Cortegiani, Andrea and Bahad, Zeynep and Erdem, Hakan},
   article_location = {CAMBRIDGE},
   article_number = {14},
   doi = {http://dx.doi.org/10.1016/j.heliyon.2024.e34325},
   keywords = {COVID-19; COVID-19-associated aspergillosis; Intensive care unit; Mortality},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study},
   url = {https://www.sciencedirect.com/science/article/pii/S2405844024103568?via%3Dihub},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2421642
AU  - Sahin, Meyha - Yilmaz, Mesut - Mert, Ali - Emecen, Ahmet Naci - Al Maslamani, Muna A Rahman S. - Hashim, Samar Mahmoud A - Ittaman, Ajithkumar Valooparambil - Wadi, Al Ramahi Jamal - Szabo, Balint Gergely - Konopnicki, Deborah - Elik, Dilsah Baskol - Lakatos, Botond - Sipahi, Oguz Resat - Khedr, Reham - Jalal, Sabah - Pshenichnaya, Natalia - Magdalena, Dumitru Irina - El-Kholy, Amani - Khan, Ejaz Ahmed - Alkan, Sevil - Hakamifard, Atousa - Sincan, Gulden - Esmaoglu, Aliye - Makek, Mateja Jankovic - Gurbuz, Esra - Liskova, Anna - Albayrak, Ayse - Stebel, Roman - Ulusoy, Tulay Unver - Ripon, Rezaul Karim - Moroti, Ruxandra - Dascalu, Cosmin - Rashid, Naveed - Cortegiani, Andrea - Bahad, Zeynep - Erdem, Hakan
PY  - 2024
TI  - Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study
JF  - Heliyon
VL  - 10
IS  - 14
SP  - 1-11
EP  - 1-11
PB  - CELL PRESS
SN  - 24058440
KW  - COVID-19
KW  - COVID-19-associated aspergillosis
KW  - Intensive care unit
KW  - Mortality
UR  - https://www.sciencedirect.com/science/article/pii/S2405844024103568?via%3Dihub
N2  - Background: This study aimed to identify factors that influence the mortality rate of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA). Methods: In this cross-sectional study, data from 23 centers across 15 countries, spanning the period of March 2020 to December 2021, were retrospectively collected. The study population comprised patients who developed invasive pulmonary aspergillosis while being treated for COVID-19 in the intensive care unit. Cox regression and decision tree analyses were used to identify factors associated with mortality in patients with CAPA. Results: A total of 162 patients (males, 65.4 %; median age: 64 [25th-75th: 54.0-73.8] years) were included in the study, of whom 113 died during the 90-day follow-up period. The median duration from CAPA diagnosis to death was 12 (25th-75th: 7-19) days. In the multivariable Cox regression model, an age of >= 65 years (hazard ratio [HR]: 2.05, 95 % confidence interval [CI]: 1.37-3.07), requiring vasopressor therapy at the time of CAPA diagnosis (HR: 1.80, 95 % CI: 1.17-2.76), and receiving renal replacement therapy at the time of CAPA diagnosis (HR: 2.27, 95 % CI: 1.35-3.82) were identified as predictors of mortality. Decision tree analysis revealed that patients with CAPA aged >= 65 years who received corticosteroid treatment for COVID-19 displayed higher mortality rates (estimated rate: 1.6, observed in 46 % of patients). Conclusion: This study concluded that elderly patients with CAPA who receive corticosteroids are at a significantly higher risk of mortality, particularly if they experience multiorgan failure.
ER  -

SAHIN, Meyha, Mesut YILMAZ, Ali MERT, Ahmet Naci EMECEN, Muna A Rahman S. AL MASLAMANI, Samar Mahmoud A HASHIM, Ajithkumar Valooparambil ITTAMAN, Al Ramahi Jamal WADI, Balint Gergely SZABO, Deborah KONOPNICKI, Dilsah Baskol ELIK, Botond LAKATOS, Oguz Resat SIPAHI, Reham KHEDR, Sabah JALAL, Natalia PSHENICHNAYA, Dumitru Irina MAGDALENA, Amani EL-KHOLY, Ejaz Ahmed KHAN, Sevil ALKAN, Atousa HAKAMIFARD, Gulden SINCAN, Aliye ESMAOGLU, Mateja Jankovic MAKEK, Esra GURBUZ, Anna LISKOVA, Ayse ALBAYRAK, Roman STEBEL, Tulay Unver ULUSOY, Rezaul Karim RIPON, Ruxandra MOROTI, Cosmin DASCALU, Naveed RASHID, Andrea CORTEGIANI, Zeynep BAHAD and Hakan ERDEM. Factors affecting mortality in COVID-19-associated pulmonary aspergillosis: An international ID-IRI study. \textit{Heliyon}. CAMBRIDGE: CELL PRESS, 2024, vol.~10, No~14, p.~1-11. ISSN~2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2024.e34325.

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