LI, Jiayin, Runze LIU, Pengfei LIU and Hu ZHOU. Simple preparation and high activity for cancer therapy via Zr (IO3)4 nanozyme. Journal of Molecular Structure. Amsterdam: Elsevier, 2024, vol. 1297, Part 2, p. 1-8. ISSN 0022-2860. Available from: https://dx.doi.org/10.1016/j.molstruc.2023.136948.
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Basic information
Original name Simple preparation and high activity for cancer therapy via Zr (IO3)4 nanozyme
Authors LI, Jiayin, Runze LIU (156 China, guarantor, belonging to the institution), Pengfei LIU and Hu ZHOU.
Edition Journal of Molecular Structure, Amsterdam, Elsevier, 2024, 0022-2860.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.800 in 2022
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.molstruc.2023.136948
UT WoS 001109362200001
Keywords in English Reactive oxygen species; Nanozyme; Cancer; Selectivity
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michaela Hylsová, Ph.D., učo 211937. Changed: 8/8/2024 08:02.
Abstract
The reactive oxygen species (ROS) level as an hopeful strategy for cancer therapy, mainly including photodynamic therapy (PDT) and chemodynamic therapy (CDT). It is well known both PDT and CDT greatly rely on oxygen reliance, inherent flaws of traditional photosensitizers, and lowly selectivity between normal cells and tumor cells. Herein, we reported Zr(IO3)4 nanoparticles as a biocompatible nanozyme with effective ROS supply by Feton-like reaction and Brady reaction. The Zr(IO3)4 exhibiting a remarkable selectivity between normal cells and tumor cells. Importantly, the Zr(IO3)4, H2O2-responsive and GSH-depleted nanozymes, were explored for tumor therapy. Nanozyme is highly important from the deep cancer therapy point of view. In this work, we prepared Zr(IO3)4 by a simple method. The obtained Zr(IO3)4 samples showed obvious performance in treatment of cancer. It was confirmed by the electron spin resonance (ESR) as well as the fluorescence probe results of Zr (IO3)4 that the treatment of cancer due to the reactive oxygen species.
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