The interplay of transition metals in ferroptosis and pyroptosis

VÁŇA, František, Zoltán SZABÓ, Michal MASAŘÍK and Monika KRATOCHVÍLOVÁ. The interplay of transition metals in ferroptosis and pyroptosis. Cell Division. London: BMC, 2024, vol. 19, No 1, p. 1-26. ISSN 1747-1028. Available from: https://dx.doi.org/10.1186/s13008-024-00127-9.

Basic information

• Original name: The interplay of transition metals in ferroptosis and pyroptosis
• Authors: VÁŇA, František (203 Czech Republic, belonging to the institution), Zoltán SZABÓ (703 Slovakia, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, belonging to the institution) and Monika KRATOCHVÍLOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Cell Division, London, BMC, 2024, 1747-1028.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.300 in 2022
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s13008-024-00127-9
• UT WoS: 001282976300001
• Keywords in English: ferroptosis; pyroptosis; transition metals; interplay
• Tags: 14110515, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Cell death is one of the most important mechanisms of maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms of necrosis-like cell death. These cell death modalities play key roles in the pathophysiology of cancer, cardiovascular, neurological diseases, and other pathologies. Transition metals are abundant group of elements in all living organisms. This paper presents a summary of ferroptosis and pyroptosis pathways and their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), and one crucial element, selenium (Se). Authors aim to summarize the up-to-date knowledge of this topic. In this review, there are categorized and highlighted the most common patterns in the alterations of ferroptosis and pyroptosis by transition metals. Special attention is given to zinc since collected data support its dual nature of action in both ferroptosis and pyroptosis. All findings are presented together with a brief description of major biochemical pathways involving mentioned metals and are visualized in attached comprehensive figures. This work concludes that the majority of disruptions in the studied metals’ homeostasis impacts cell fate, influencing both death and survival of cells in the complex system of altered pathways. Therefore, this summary opens up the space for further research.

Links

• MUNI/A/1547/2023, interní kód MU: Name: Analýza (dys)funkce: od molekul k živému organismu

Investor: Masaryk University, Analysis of (dys)function: from molecules to the living organism

• MUNI/A/1587/2023, interní kód MU: Name: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masaryk University, Pathophysiology of selected complex diseases from molecular to systemic level