Predictors of spontaneous intracerebral hemorrhage mortality: a
community-based study in Brno, Czech Republic

J 2024

Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR et. al.

Basic information

Original name

Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic

Authors

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK and Robert MIKULÍK

Edition

Acta Neurologica Belgica, Heidelberg, Springer Heidelberg, 2024, 0300-9009

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s13760-024-02612-y

UT WoS

001284655800001

Keywords in English

Czech Republic; Intracerebral hemorrhage; Mortality; Community-based study

Abstract

V originále

Background and objective Intracerebral hemorrhage (ICH) is a serious medical condition with high mortality. However, factors leading to long-term mortality after ICH are largely unclear. The aim of this community-based study is to assess predictors of long-term mortality after spontaneous ICH. Methods We identified all patients admitted with spontaneous ICH to hospitals with a certified stroke unit in Brno, the second largest city in the Czech Republic (CR), in 2011, the year of the Czech Population and Housing Census. We reviewed their medical records for risk factors, radiographic parameters, and measures of post-stroke neurological deficit [National Institutes of Health Stroke Scale (NIHSS)]. Using the dates of death from the Czech National Mortality Register, we calculated mortality at 30 days, six months, one year, and three years after the ICH. Multivariate analysis with forward stepwise logistic regression was performed to determine independent predictors of mortality (p < 0.05). Results In 2011, 1086 patients with stroke were admitted to the four stroke-certified hospitals in Brno, CR. Of these, 134 had spontaneous ICH, with complete data available in 93 of them entering the final analysis. The mortality at 30 days, 6 months, 1 year, and 3 years post-ICH was 34%, 47%, 51%, and 63%, respectively. The mortality was highest in the first few days post-event, with 50% of patients dying in 255 days and average survival being 884 +/- 90 days. Both NIHSS and modified ICH (MICH) score showed to be strong and reliable predictors of short- as well as long-term mortality; the risk of death post-ICH increased with older age and size of ICH. Other risk factors contributing to higher, primarily shorter-term mortality included history of cardiac failure, myocardial infarction, or atrial fibrillation. Conclusions In our community-based study, we found that severity of neurological deficit at admission (NIHSS), combined with age and size of ICH, well predicted short- as well as long-term mortality after spontaneous ICH. A history of cardiac failure, myocardial infarction, or atrial fibrillation at presentation were also predictors of mortality, underscoring the need for optimal cardiac management in patients with ICH.

Links

LM2018128, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

NW24-09-00215, research and development project

Name: Analýza velkých dat pro záchranu životů pacientů s akutním infarktem myokardu a cévní mozkovou příhodou v České republice (MISA-BID Myocardial Infarction and Stroke Big Data Analysis)

Investor: Ministry of Health of the CR, Analysis of big data to save lives of patients with acute myocardial infarction and stroke in the Czech Republic (MISA-BID Myocardial Infarction and Stroke Big Data Analysis), Subprogram 1 - standard

Citovat

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK and Robert MIKULÍK. Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic. Acta Neurologica Belgica. Heidelberg: Springer Heidelberg, 2024, 14 pp. ISSN 0300-9009. Available from: https://dx.doi.org/10.1007/s13760-024-02612-y.

@article{2422975,
   author = {Štěrba, Albert and Šedová, Petra and Brown Jr, Robert D and Stehlík, Albert and Bryndziar, Tomáš and Cimflová, Petra and Zvolsky, Miroslav and Belaskova, Silvie and Kovacova, Ingrid and Bednařík, Josef and Mikulík, Robert},
   article_location = {Heidelberg},
   doi = {http://dx.doi.org/10.1007/s13760-024-02612-y},
   keywords = {Czech Republic; Intracerebral hemorrhage; Mortality; Community-based study},
   language = {eng},
   issn = {0300-9009},
   journal = {Acta Neurologica Belgica},
   title = {Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic},
   url = {https://link.springer.com/article/10.1007/s13760-024-02612-y},
   year = {2024}
}

TY  - JOUR
ID  - 2422975
AU  - Štěrba, Albert - Šedová, Petra - Brown Jr, Robert D - Stehlík, Albert - Bryndziar, Tomáš - Cimflová, Petra - Zvolsky, Miroslav - Belaskova, Silvie - Kovacova, Ingrid - Bednařík, Josef - Mikulík, Robert
PY  - 2024
TI  - Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic
JF  - Acta Neurologica Belgica
PB  - Springer Heidelberg
SN  - 03009009
KW  - Czech Republic
KW  - Intracerebral hemorrhage
KW  - Mortality
KW  - Community-based study
UR  - https://link.springer.com/article/10.1007/s13760-024-02612-y
N2  - Background and objective Intracerebral hemorrhage (ICH) is a serious medical condition with high mortality. However, factors leading to long-term mortality after ICH are largely unclear. The aim of this community-based study is to assess predictors of long-term mortality after spontaneous ICH. Methods We identified all patients admitted with spontaneous ICH to hospitals with a certified stroke unit in Brno, the second largest city in the Czech Republic (CR), in 2011, the year of the Czech Population and Housing Census. We reviewed their medical records for risk factors, radiographic parameters, and measures of post-stroke neurological deficit [National Institutes of Health Stroke Scale (NIHSS)]. Using the dates of death from the Czech National Mortality Register, we calculated mortality at 30 days, six months, one year, and three years after the ICH. Multivariate analysis with forward stepwise logistic regression was performed to determine independent predictors of mortality (p < 0.05). Results In 2011, 1086 patients with stroke were admitted to the four stroke-certified hospitals in Brno, CR. Of these, 134 had spontaneous ICH, with complete data available in 93 of them entering the final analysis. The mortality at 30 days, 6 months, 1 year, and 3 years post-ICH was 34%, 47%, 51%, and 63%, respectively. The mortality was highest in the first few days post-event, with 50% of patients dying in 255 days and average survival being 884 +/- 90 days. Both NIHSS and modified ICH (MICH) score showed to be strong and reliable predictors of short- as well as long-term mortality; the risk of death post-ICH increased with older age and size of ICH. Other risk factors contributing to higher, primarily shorter-term mortality included history of cardiac failure, myocardial infarction, or atrial fibrillation. Conclusions In our community-based study, we found that severity of neurological deficit at admission (NIHSS), combined with age and size of ICH, well predicted short- as well as long-term mortality after spontaneous ICH. A history of cardiac failure, myocardial infarction, or atrial fibrillation at presentation were also predictors of mortality, underscoring the need for optimal cardiac management in patients with ICH.
ER  -

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK and Robert MIKULÍK. Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic. \textit{Acta Neurologica Belgica}. Heidelberg: Springer Heidelberg, 2024, 14 pp. ISSN~0300-9009. Available from: https://dx.doi.org/10.1007/s13760-024-02612-y.

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