Detailed Information on Publication Record
2024
Rare multi-fungal sepsis: a case of triple-impact immunoparalysis
LIPOVÝ, Břetislav, Martin HLADÍK, Kateřina VYKLICKÁ, Iva KOCMANOVÁ, Martina LENGEROVÁ et. al.Basic information
Original name
Rare multi-fungal sepsis: a case of triple-impact immunoparalysis
Authors
LIPOVÝ, Břetislav (203 Czech Republic, belonging to the institution), Martin HLADÍK (703 Slovakia, belonging to the institution), Kateřina VYKLICKÁ (203 Czech Republic, belonging to the institution), Iva KOCMANOVÁ (203 Czech Republic), Martina LENGEROVÁ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Michal SRNÍK (203 Czech Republic, belonging to the institution), Jan BÖHM (203 Czech Republic, belonging to the institution), Petr ANDRLA (203 Czech Republic, belonging to the institution) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Folia microbiologica, Praha, Mikrobiologický ústav Praha AV ČR, 2024, 0015-5632
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30405 Medical biotechnology related ethics
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.600 in 2022
Organization unit
Faculty of Medicine
UT WoS
001206029000001
Keywords in English
Mycobiome; COVID-19; Isavuconazole; Inhalation injury
Tags
International impact, Reviewed
Změněno: 15/8/2024 12:59, Mgr. Tereza Miškechová
Abstract
V originále
Patients with burn injury and inhalation injury are highly susceptible to infectious complications, including opportunistic pathogens, due to the loss of skin cover and mucosal damage of respiratory tract as well as the disruption of homeostasis. This case report, a 34-year-old man suffered critical burns, provides the first literature description of triple-impact immunoparalysis (critical burns, inhalation injury, and SARS-CoV-2 infection), leading to a lethal multifocal infection caused by several fungi including very rare environmental representatives Metschnikowia pulcherrima and Wickerhamomyces anomalus. The co-infection by these common environmental yeasts in a human is unique and has not yet been described in the literature. Importantly, our patient developed refractory septic shock and died despite targeted antifungal therapy including the most potent current antifungal agent-isavuconazole. It can be assumed that besides immunoparalysis, effectiveness of therapy by isavuconazole was impaired by the large distribution volume in this case. As this is a common situation in intensive care patients, routine monitoring of plasmatic concentration of isavuconazole can be helpful in personalization of the treatment and dose optimization. Whatmore, many fungal species often remain underdiagnosed during infectious complications, which could be prevented by implementation of new methods, such as next-generation sequencing, into clinical practice.
Links
| LM2023069, research and development project |
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