The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in
presumed healthy infants

J 2024

The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants

BAJEROVA, Katerina, Karolina HRABCOVA and Yvan VANDENPLAS

Basic information

Original name

The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants

Authors

BAJEROVA, Katerina, Karolina HRABCOVA and Yvan VANDENPLAS

Edition

European journal of pediatrics, New York, Springer, 2024, 0340-6199

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.600 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00431-024-05693-2

UT WoS

001280806200002

Keywords in English

CoMiSS; Awareness tool; Cow's milk allergy

Abstract

V originále

The Cow's Milk-related Symptom Score (CoMiSS (TM)) is a scoring system that reflects the appearance and intensity of symptoms possibly related to consumption of cow's milk. The original tool was recently updated by changing the cut-off, and the stool scale and by adding angioedema. There is no data available regarding the natural evolution of CoMiSS in infants with no cow's milk allergy (no-CMA) or a comparison between original and updated CoMiSS values. We determined the original and the updated CoMiSS in infants not diagnosed with cow's milk allergy. The evolution of CoMiSS during the first year of life was assessed repetitively during predefined check-ups at 1.5, 3, 4, 6, 8, 10, and 12 months. The original and updated scores were compared with the Wilcoxon Signed-Rank Test. We also tested the impact of feeding type, age, gender, and order in the family on the CoMiSS. One hundred and twenty-two infants were included. CoMiSS values during the first year of life showed an inverse relation to age. The difference in CoMiSS between the original and updated versions was significant at 6,8,10, and 12 months (p < 0.001), related to the switch from the Bristol Stool Form Scale to the Brussels Infants and Toddlers Stool Scale (BITSS). The difference between both versions of CoMiSS was not significantly different in infants < 6 months (p = 0.999 at 1.5 and 4 months, and p = 0.586 at 3 months, respectively). Conclusion: CoMiSS decreases with age during the first year of life. While there is no difference between the two CoMiSS versions in healthy infants under 6 months of age, the CoMiSS value in the updated version is lower than the original 1 in infants aged 6 to 12 months.

Citovat

BAJEROVA, Katerina, Karolina HRABCOVA and Yvan VANDENPLAS. The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants. European journal of pediatrics. New York: Springer, 2024, 7 pp. ISSN 0340-6199. Available from: https://dx.doi.org/10.1007/s00431-024-05693-2.

@article{2423144,
   author = {Bajerova, Katerina and Hrabcova, Karolina and Vandenplas, Yvan},
   article_location = {New York},
   doi = {http://dx.doi.org/10.1007/s00431-024-05693-2},
   keywords = {CoMiSS; Awareness tool; Cow's milk allergy},
   language = {eng},
   issn = {0340-6199},
   journal = {European journal of pediatrics},
   title = {The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants},
   url = {https://link.springer.com/article/10.1007/s00431-024-05693-2},
   year = {2024}
}

TY  - JOUR
ID  - 2423144
AU  - Bajerova, Katerina - Hrabcova, Karolina - Vandenplas, Yvan
PY  - 2024
TI  - The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants
JF  - European journal of pediatrics
PB  - Springer
SN  - 03406199
KW  - CoMiSS
KW  - Awareness tool
KW  - Cow's milk allergy
UR  - https://link.springer.com/article/10.1007/s00431-024-05693-2
N2  - The Cow's Milk-related Symptom Score (CoMiSS (TM)) is a scoring system that reflects the appearance and intensity of symptoms possibly related to consumption of cow's milk. The original tool was recently updated by changing the cut-off, and the stool scale and by adding angioedema. There is no data available regarding the natural evolution of CoMiSS in infants with no cow's milk allergy (no-CMA) or a comparison between original and updated CoMiSS values. We determined the original and the updated CoMiSS in infants not diagnosed with cow's milk allergy. The evolution of CoMiSS during the first year of life was assessed repetitively during predefined check-ups at 1.5, 3, 4, 6, 8, 10, and 12 months. The original and updated scores were compared with the Wilcoxon Signed-Rank Test. We also tested the impact of feeding type, age, gender, and order in the family on the CoMiSS. One hundred and twenty-two infants were included. CoMiSS values during the first year of life showed an inverse relation to age. The difference in CoMiSS between the original and updated versions was significant at 6,8,10, and 12 months (p < 0.001), related to the switch from the Bristol Stool Form Scale to the Brussels Infants and Toddlers Stool Scale (BITSS). The difference between both versions of CoMiSS was not significantly different in infants < 6 months (p = 0.999 at 1.5 and 4 months, and p = 0.586 at 3 months, respectively). Conclusion: CoMiSS decreases with age during the first year of life. While there is no difference between the two CoMiSS versions in healthy infants under 6 months of age, the CoMiSS value in the updated version is lower than the original 1 in infants aged 6 to 12 months.
ER  -

BAJEROVA, Katerina, Karolina HRABCOVA and Yvan VANDENPLAS. The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants. \textit{European journal of pediatrics}. New York: Springer, 2024, 7 pp. ISSN~0340-6199. Available from: https://dx.doi.org/10.1007/s00431-024-05693-2.

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