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@article{2423159,
author = {Dastych, Milan and Holánek, Miloš and Gottwaldova, Jana and Cermakova, Zdenka and Mikuskova, Alena},
article_location = {ABINGDON},
doi = {http://dx.doi.org/10.1080/00365513.2024.2369982},
keywords = {Neoadjuvant chemotherapy; breast cancer; amino acids; plasma proteins; nitrogen metabolism},
language = {eng},
issn = {0036-5513},
journal = {SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION},
title = {Impact of breast cancer neoadjuvant chemotherapy on plasma and urine amino acid profile, plasma proteins and nitrogen metabolism},
url = {https://www.tandfonline.com/doi/full/10.1080/00365513.2024.2369982},
year = {2024}
}
TY - JOUR
ID - 2423159
AU - Dastych, Milan - Holánek, Miloš - Gottwaldova, Jana - Cermakova, Zdenka - Mikuskova, Alena
PY - 2024
TI - Impact of breast cancer neoadjuvant chemotherapy on plasma and urine amino acid profile, plasma proteins and nitrogen metabolism
JF - SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
PB - INFORMA HEALTHCARE
SN - 00365513
KW - Neoadjuvant chemotherapy
KW - breast cancer
KW - amino acids
KW - plasma proteins
KW - nitrogen metabolism
UR - https://www.tandfonline.com/doi/full/10.1080/00365513.2024.2369982
N2 - Neoadjuvant chemotherapy (NAC) is the preferred treatment option in locally advanced breast cancer (BC). The administration of NAC is associated with a wide range of adverse effects. This pilot observational prospective study examined the effect of NAC using anthracycline + cyclophosphamide (AC) followed by paclitaxel (PTx) on a portfolio of 22 plasma and urinary amino acids, plasma proteins (albumin, prealbumin, transferrin), and products of nitrogen metabolism (urea, creatinine, uric acid) in plasma and urine. Plasma and 24-h urine samples were obtained from ten patients with early breast cancer (N1-3 N0-2 M0), at the following time points: before the start of NAC and during the AC/PTx treatment period (a total of 8 measurements at three-weekly intervals). Amino acids were analyzed using ion exchange chromatography. There were no significant differences in the measured parameters in plasma and urine between pre-NAC and during AC- and PTx-treatment. No trend was detected. A significant difference in the portfolio of plasma and urinary amino acids was found only in the pre-treatment period compared to the control group. Levels of eight plasma amino acids (8/22) were significantly reduced and those of nine urine amino acids were increased (9/22). Nitrogenous catabolites in plasma and urine were not indicative of increased protein catabolism during the anthracycline and taxane treatment periods. A slightly positive nitrogen balance was accompanied by an average weight gain of 3.3 kg (range 0-6 kg). The AC/PTx treatment regimen did not cause significant changes in the monitored laboratory parameters.
ER -
DASTYCH, Milan, Miloš HOLÁNEK, Jana GOTTWALDOVA, Zdenka CERMAKOVA and Alena MIKUSKOVA. Impact of breast cancer neoadjuvant chemotherapy on plasma and urine amino acid profile, plasma proteins and nitrogen metabolism. \textit{SCANDINAVIAN JOURNAL OF CLINICAL \&{}amp; LABORATORY INVESTIGATION}. ABINGDON: INFORMA HEALTHCARE, 2024, 8 pp. ISSN~0036-5513. Available from: https://dx.doi.org/10.1080/00365513.2024.2369982.
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