Total intracranial hemorrhage volume measurement summating all
compartments best in traumatic and nontraumatic intracranial
bleeding

J 2024

Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding

HORN, Mackenzie, Ankur BANERJEE, Linda MACHOVÁ, Ondřej VOLNÝ, Hyun Seok CHOI et. al.

Basic information

Original name

Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding

Authors

HORN, Mackenzie, Ankur BANERJEE, Linda MACHOVÁ (203 Czech Republic, belonging to the institution), Ondřej VOLNÝ (203 Czech Republic, belonging to the institution), Hyun Seok CHOI, Federica LETTERI, Tomoyuki OHARA, Koji TANAKA, Stuart CONNOLLY, Per LADENVALL, Mark CROWTHER, Jan BEYER-WESTENDORF, Ashkan SHOAMANESH, Andrew M DEMCHUK and Abdulaziz S AL SULTAN

Edition

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2024, 2162-3279

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.100 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/brb3.3481

UT WoS

001209357000001

Keywords in English

neuroimaging; neuroscience; neurology; stroke

Abstract

V originále

Background and purposeThe ANNEXA-4 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was traumatic and nontraumatic intracranial bleeding. Different measurements were applied in the trial including volumetrics to assess for intracranial bleeding depending on the compartment involved. We aimed to determine the most reliable way to measure intracranial hemorrhage (ICrH) volume by comparing individual brain compartment and total ICrH volume.MethodsThirty patients were randomly selected from the ANNEXA-4 database to assess measurement of ICrH volume by compartment and in total. Total and compartmental hemorrhage volumes were measured by five readers using Quantomo software. Each reader measured baseline hemorrhage volumes twice separated by 1 week. Twenty-eight different ANNEXA-4 subjects were also randomly selected to assess intra-rater reliability of total ICrH volume measurement change at baseline and 12-h follow up, performed by three readers twice to assess hemostatic efficacy categories used in ANNEXA-4.ResultsCompartmental minimal detectable change percentages (MDC%) ranged between 9.72 and 224.13, with the greatest measurement error occurring in patients with a subdural hemorrhage. Total ICrH volume measurements had the lowest MDC%, which ranged between 6.57 and 33.52 depending on the reader.ConclusionMeasurement of total ICrH volumes is more accurate than volume by compartment with less measurement error. Determination of hemostatic efficacy was consistent across readers, and within the same reader, as well as when compared to consensus read. Volumetric analysis of intracranial hemostatic efficacy is feasible and reliable when using total ICrH volumes.

Citovat

HORN, Mackenzie, Ankur BANERJEE, Linda MACHOVÁ, Ondřej VOLNÝ, Hyun Seok CHOI, Federica LETTERI, Tomoyuki OHARA, Koji TANAKA, Stuart CONNOLLY, Per LADENVALL, Mark CROWTHER, Jan BEYER-WESTENDORF, Ashkan SHOAMANESH, Andrew M DEMCHUK and Abdulaziz S AL SULTAN. Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding. Brain and Behavior. Hoboken: John Wiley and Sons Inc., 2024, vol. 14, No 5, p. 1-8. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.3481.

@article{2423197,
   author = {Horn, Mackenzie and Banerjee, Ankur and Machová, Linda and Volný, Ondřej and Choi, Hyun Seok and Letteri, Federica and Ohara, Tomoyuki and Tanaka, Koji and Connolly, Stuart and Ladenvall, Per and Crowther, Mark and BeyerandWestendorf, Jan and Shoamanesh, Ashkan and Demchuk, Andrew M and Al Sultan, Abdulaziz S},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/brb3.3481},
   keywords = {neuroimaging; neuroscience; neurology; stroke},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/brb3.3481},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2423197
AU  - Horn, Mackenzie - Banerjee, Ankur - Machová, Linda - Volný, Ondřej - Choi, Hyun Seok - Letteri, Federica - Ohara, Tomoyuki - Tanaka, Koji - Connolly, Stuart - Ladenvall, Per - Crowther, Mark - Beyer-Westendorf, Jan - Shoamanesh, Ashkan - Demchuk, Andrew M - Al Sultan, Abdulaziz S
PY  - 2024
TI  - Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding
JF  - Brain and Behavior
VL  - 14
IS  - 5
SP  - 1-8
EP  - 1-8
PB  - John Wiley and Sons Inc.
SN  - 21623279
KW  - neuroimaging
KW  - neuroscience
KW  - neurology
KW  - stroke
UR  - https://onlinelibrary.wiley.com/doi/10.1002/brb3.3481
N2  - Background and purposeThe ANNEXA-4 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was traumatic and nontraumatic intracranial bleeding. Different measurements were applied in the trial including volumetrics to assess for intracranial bleeding depending on the compartment involved. We aimed to determine the most reliable way to measure intracranial hemorrhage (ICrH) volume by comparing individual brain compartment and total ICrH volume.MethodsThirty patients were randomly selected from the ANNEXA-4 database to assess measurement of ICrH volume by compartment and in total. Total and compartmental hemorrhage volumes were measured by five readers using Quantomo software. Each reader measured baseline hemorrhage volumes twice separated by 1 week. Twenty-eight different ANNEXA-4 subjects were also randomly selected to assess intra-rater reliability of total ICrH volume measurement change at baseline and 12-h follow up, performed by three readers twice to assess hemostatic efficacy categories used in ANNEXA-4.ResultsCompartmental minimal detectable change percentages (MDC%) ranged between 9.72 and 224.13, with the greatest measurement error occurring in patients with a subdural hemorrhage. Total ICrH volume measurements had the lowest MDC%, which ranged between 6.57 and 33.52 depending on the reader.ConclusionMeasurement of total ICrH volumes is more accurate than volume by compartment with less measurement error. Determination of hemostatic efficacy was consistent across readers, and within the same reader, as well as when compared to consensus read. Volumetric analysis of intracranial hemostatic efficacy is feasible and reliable when using total ICrH volumes.
ER  -

HORN, Mackenzie, Ankur BANERJEE, Linda MACHOVÁ, Ondřej VOLNÝ, Hyun Seok CHOI, Federica LETTERI, Tomoyuki OHARA, Koji TANAKA, Stuart CONNOLLY, Per LADENVALL, Mark CROWTHER, Jan BEYER-WESTENDORF, Ashkan SHOAMANESH, Andrew M DEMCHUK and Abdulaziz S AL SULTAN. Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2024, vol.~14, No~5, p.~1-8. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.3481.

Detailed Information on Publication Record