MATEJICKA, Peter, Slavomir KAJAN, Jozef GOGA, Igor STRAKA, Marek BALÁŽ, Simon JANOVIC, Michal MINAR, Peter VALKOVIC, Michal HAJDUK and Zuzana KOSUTZKA. Bradykinesia in dystonic hand tremor: kinematic analysis and clinical rating. Frontiers in Human Neuroscience. Lausanne: FRONTIERS MEDIA SA, 2024, vol. 18, June 2024, p. 1-9. ISSN 1662-5161. Available from: https://dx.doi.org/10.3389/fnhum.2024.1395827.
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Basic information
Original name Bradykinesia in dystonic hand tremor: kinematic analysis and clinical rating
Authors MATEJICKA, Peter, Slavomir KAJAN, Jozef GOGA, Igor STRAKA, Marek BALÁŽ (703 Slovakia, belonging to the institution), Simon JANOVIC, Michal MINAR, Peter VALKOVIC, Michal HAJDUK and Zuzana KOSUTZKA.
Edition Frontiers in Human Neuroscience, Lausanne, FRONTIERS MEDIA SA, 2024, 1662-5161.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.900 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3389/fnhum.2024.1395827
UT WoS 001255206600001
Keywords in English dystonic tremor; bradykinesia; finger tapping; kinematic analysis; blinded clinical rating
Tags 14110127
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 16/8/2024 07:51.
Abstract
Introduction Bradykinesia is an essential diagnostic criterion for Parkinson's disease (PD) but is frequently observed in many non-parkinsonian movement disorders, complicating differential diagnosis, particularly in disorders featuring tremors. The presence of bradykinetic features in the subset of dystonic tremors (DT), either "pure" dystonic tremors or tremors associated with dystonia, remains currently unexplored. The aim of the current study was to evaluate upper limb bradykinesia in DT patients, comparing them with healthy controls (HC) and patients with PD by observing repetitive finger tapping (FT).Methods The protocol consisted of two main parts. Initially, the kinematic recording of repetitive FT was performed using optical hand tracking system (Leap Motion Controller). The values of amplitude, amplitude decrement, frequency, frequency decrement, speed, acceleration and number of halts of FT were calculated. Subsequently, three independent movement disorder specialists from different movement disorders centres, blinded to the diagnosis, rated the presence of FT bradykinesia based on video recordings.Results Thirty-six subjects participated in the study (12 DT, 12 HC and 12 early-stage PD). Kinematic analysis revealed no significant difference in the selected parameters of FT bradykinesia between DT patients and HC. In comparisons between DT and PD patients, PD patients exhibited bigger amplitude decrement and slower FT performance. In the blinded clinical assessment, bradykinesia was rated, on average, as being present in 41.6% of DT patients, 27.7% of HC, and 91.7% of PD patients. While overall inter-rater agreement was moderate, weak agreement was noted within the DT group.Discussion Clinical ratings indicated signs of bradykinesia in almost half of DT patients. The objective kinematic analysis confirmed comparable parameters between DT and HC individuals, with more pronounced abnormalities in PD across various kinematic parameters. Interpretation of bradykinesia signs in tremor patients with DT should be approached cautiously and objective motion analysis might complement the diagnostic process and serve as a decision support system in the choice of clinical entities.
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